Reward-related neural dysfunction in youth with a history of suicidal ideation: The importance of temporal predictability.
Reward-related neural dysfunction in youth with a history of suicidal ideation: The importance of temporal predictability.
复制标题
DOI：
10.1016/j.jpsychires.2022.11.036
复制
发表时间：
2022-12
影响因子：
4.8
通讯作者：
S. Gorka;Charles A. Manzler;Emily E. Jones;Reid J. Smith;C. Bryan
中科院分区：
文献类型：
--
作者：
S. Gorka;Charles A. Manzler;Emily E. Jones;Reid J. Smith;C. Bryan
不正常的报酬处理是自杀的一个重要但尚未得到充分研究的危险因素。最近的神经成像研究发现，自杀与与奖励相关的异常神经反应和大脑广泛区域和回路的连接有关。这些不同的，而且经常是不一致的发现阻碍了在阐明奖赏处理功能障碍和自杀风险之间的神经生物学联系方面的进展。其中一些差异可能与研究中使用的不同奖励相关范式有关。目前这项研究的主要目的是通过比较有和没有自杀意念史的年轻人在直接操纵奖励参数时的神经反应来解决这些问题。将108例17~19岁未服药青年分为两组：1)有自杀意念史(n=39)；(2)无自杀意念史(n=669)。所有参与者都完成了一项新的奖赏预期任务，探索对可预测(P-奖赏)和不可预测(U-奖赏)金钱奖赏的预期。结果显示，与对照组相比，有自杀意念史的青少年在期待U奖赏时，其背侧前扣带回(DACC)和右前岛(Ans)的神经活动增加。在对P奖赏的预期过程中，不存在群体差异。这些发现表明，自杀意念的倾向可能与预期U-奖赏时的特定异常有关，但与P-奖赏无关。
Abnormal reward processing is an important yet understudied risk factor for suicide. Recent neuroimaging studies have found that suicidality is associated with abnormal reward-related neural reactivity and connectivity across a wide range of brain regions and circuits. The varying, and oftentimes discrepant, findings have hindered progress in elucidating the neurobiological link between reward processing dysfunction and suicide risk. Some of this variability is likely related to different reward-related paradigms that are utilized across studies. The primary aim of the current study was to address these issues by comparing neural reactivity between youth with and without a history of suicidal ideation during direct manipulation of reward parameters. A total of 108 unmedicated youth, ages 17–19, were classified into two groups: 1) history of suicidal ideation (n = 39) and 2) no history of suicidal ideation (n = 69). All participants completed a novel reward anticipation task probing anticipation of predictable (P-reward) and unpredictable (U-reward) monetary reward. Results revealed that compared with controls, youth with a history of suicidal ideation exhibited increased neural activation in the dorsal anterior cingulate cortex (dACC) and right anterior insula (aINS) during anticipation of U-reward. There were no group differences during anticipation of P-reward. These findings suggest that propensity for suicidal ideation may be related to specific abnormalities during anticipation of U-reward, but not P-reward.