Functional connectivity variations in mild cognitive impairment: associations with cognitive function.
Functional connectivity variations in mild cognitive impairment: associations with cognitive function.
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DOI：
10.1017/s1355617711001299
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发表时间：
2012-01
影响因子：
2.6
通讯作者：
Bennett, David A.
中科院分区：
文献类型：
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作者：
Han, S. Duke;Arfanakis, Konstantinos;Fleischman, Debra A.;Leurgans, Sue E.;Tuminello, Elizabeth R.;Edmonds, Emily C.;Bennett, David A.
关键词：
有轻度认知障碍(MCI)的参与者比没有MCI的参与者患阿尔茨海默病(AD)的可能性更高，对MCI参与者进行的功能磁共振神经成像(FMRI)可能被证明是识别AD早期生物标志物的重要工具。我们使用静息状态功能磁共振成像测试了患有和不患有MCI的老年人之间存在功能连接差异的假设。数据收集了超过200名参与者的Rush Memory and Aging Project，这是一项基于社区的、关于衰老的临床病理队列研究。从队列中，40名参与者被确认为MCI，并与40名人口统计匹配的无认知障碍的参与者进行比较。MCI受试者后扣带回皮质与左右眶前区、右侧额中区、左壳核、右侧尾状核、左侧颞叶上区和右侧后扣带区之间的功能连接较弱，而与右额下部、左侧梭形、左侧直肠和左侧中央前区域的连接较强。此外，在113个替代样本中，不同区域的连接值与情景记忆和处理速度相关。结果表明，不同区域的功能连接值与认知功能有关，可能反映了AD病理的存在和发展为临床AD的风险增加。
Participants with mild cognitive impairment (MCI) have a higher likelihood of developing Alzheimer's disease (AD) compared to those without MCI, and functional magnetic resonance neuroimaging (fMRI) used with MCI participants may prove to be an important tool in identifying early biomarkers for AD. We tested the hypothesis that functional connectivity differences exist between older adults with and without MCI using resting-state fMRI. Data were collected on over 200 participants of the Rush Memory and Aging Project, a community-based, clinical-pathological cohort study of aging. From the cohort, 40 participants were identified as having MCI, and were compared to 40 demographically matched participants without cognitive impairment. MCI participants showed lesser functional connectivity between the posterior cingulate cortex and right and left orbital frontal, right middle frontal, left putamen, right caudate, left superior temporal, and right posterior cingulate regions; and greater connectivity with right inferior frontal, left fusiform, left rectal, and left precentral regions. Furthermore, in an alternate sample of 113, connectivity values in regions of difference correlated with episodic memory and processing speed. Results suggest functional connectivity values in regions of difference are associated with cognitive function and may reflect the presence of AD pathology and increased risk of developing clinical AD.