Self-assembling peptides for stem cell and tissue engineering.
Self-assembling peptides for stem cell and tissue engineering.
复制标题
DOI：
10.1039/c5bm00550g
复制
发表时间：
2016-04
影响因子：
6.6
通讯作者：
Kim DH
中科院分区：
文献类型：
--
作者：
Tatman PD;Muhonen EG;Wickers ST;Gee AO;Kim ES;Kim DH
再生医学在解决当前医学疗法的许多缺点方面具有巨大的潜力。再生医学的一个新兴途径是使用自组装肽（SAP）结合干细胞来改善受损组织的修复。特定的肽序列、机械性质和纳米形貌线索在不同的SAP之间变化很大，其中许多SAP已用于类似组织的再生。为了评估SAP引导干细胞命运的潜力，我们广泛回顾了SAP和干细胞分化的文献报道。为了描绘这些研究的最准确的总结，我们故意讨论成功和陷阱，使我们能够得出跨越这个令人兴奋的领域的结论。我们还扩大了这些结论，将这些研究结果与纳米地形学，机械转导和特定组织中细胞外基质的天然组成领域，以确定未来研究的潜在方向。
Regenerative medicine holds great potential to address many shortcomings in current medical therapies. An emerging avenue of regenerative medicine is the use of self-assembling peptides (SAP) in conjunction with stem cells to improve the repair of damaged tissues. The specific peptide sequence, mechanical properties, and nanotopographical cues vary widely between different SAPs, many of which have been used for the regeneration of similar tissues. To evaluate the potential of SAPs to guide stem cell fate, we extensively reviewed the literature for reports of SAPs and stem cell differentiation. To portray the most accurate summary of these studies, we deliberately discuss both the successes and pitfalls, allowing us to make conclusions that span the breadth of this exciting field. We also expand on these conclusions by relating these findings to the fields of nanotopography, mechanotransduction, and the native composition of the extracellular matrix in specific tissues to identify potential directions for future research.