A new type of tripropeptin with anteiso-branched chain fatty acid from Lysobacter sp BMK333-48F3
A new type of tripropeptin with anteiso-branched chain fatty acid from Lysobacter sp BMK333-48F3
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DOI：
10.1038/ja.2008.78
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发表时间：
2008-09-01
影响因子：
3.3
通讯作者：
Akamatsu, Yuzuru
中科院分区：
文献类型：
--
作者：
Hashizume, Hideki;Igarashi, Masayuki;Akamatsu, Yuzuru
支链氨基酸通常被用作许多含脂细菌次级代谢产物的前体。异亮氨酸对来自溶杆菌属的环状脂肽抗生素、三丙肽的混合物的组成的影响。对 BMK333-48F3 进行了评估。正如预期的那样，产生了一种具有反异支链脂肪酸的新型三肽肽类似物。新化合物 TPPaiC 对革兰氏阳性菌（包括 MRSA 和 VRE）表现出强大的抗菌活性。另一方面，没有观察到通过添加异亮氨酸而增加其他三前肽素的产量。
Branched chain amino acids are often utilized as the precursors of many lipid-containing bacterial secondary metabolites. The effect of isoleucine on the composition of the mixture of cyclic lipopeptide antibiotics, tripropeptins from Lysobacter sp. BMK333-48F3 was evaluated. As expected, a novel tripropeptin analog with an anteiso-branched fatty acid was produced. The new compound, TPPaiC shows potent antibacterial activity against Gram-positive bacteria including MRSA and VRE. On the other hand, no increase was observed in the production of other tripropeptins by the addition of isoleucine.