Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.
Neuronal generator patterns of olfactory event-related brain potentials in schizophrenia.
复制标题
精神分裂症中嗅觉事件相关脑电位的神经元发生器模式。
DOI：
10.1111/j.1469-8986.2010.01013.x
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发表时间：
2010
期刊：
影响因子：
3.7
通讯作者：
Bruder,GerardE
中科院分区：
文献类型：
--
作者：
Kayser,Jürgen;Tenke,CraigE;Malaspina,Dolores;Kroppmann,ChristopherJ;Schaller,JenniferD;Deptula,Andrew;Gates,NathanA;Harkavy-Friedman,JillM;Gil,Roberto;Bruder,GerardE
为了更好地表征精神分裂症嗅觉功能障碍的神经生理过程，在硫化氢检测过程中记录了 32 名患者和 35 名健康成年人（18 名和 18 名男性）的鼻参考 30 通道脑电图（恒流嗅觉计，200 毫秒非鼻暴露）。事件相关电位 (ERP) 转换为无参考电流源密度 (CSD) 波形，并通过无限制 Varimax-PCA 进行分析。参与者在感知到高（10 ppm）或低（50% 稀释）气味浓度时表示。患者和对照组在高强度（23% 遗漏）和低强度（43%）的检测方面没有差异，并且也具有相似的嗅觉 ERP 波形。 CSD 显示高强度的双侧额颞 N1 汇（305 毫秒）和中顶叶 P2 源（630 毫秒）比低强度更大。在高强度刺激下，患者的 N1 汇和 P2 源显着减少，这为精神分裂症嗅觉功能障碍提供了进一步的神经生理学证据。
To better characterize neurophysiologic processes underlying olfactory dysfunction in schizophrenia, nose–referenced 30–channel electroencephalogram was recorded from 32 patients and 35 healthy adults (18 and 18 male) during detection of hydrogen sulfide (constant‐flow olfactometer, 200 ms unirhinal exposure). Event‐related potentials (ERPs) were transformed to reference–free current source density (CSD) waveforms and analyzed by unrestricted Varimax–PCA. Participants indicated when they perceived a high (10 ppm) or low (50% dilution) odor concentration. Patients and controls did not differ in detection of high (23% misses) and low (43%) intensities and also had similar olfactory ERP waveforms. CSDs showed a greater bilateral frontotemporal N1 sink (305 ms) and mid‐parietal P2 source (630 ms) for high than low intensities. N1 sink and P2 source were markedly reduced in patients for high intensity stimuli, providing further neurophysiological evidence of olfactory dysfunction in schizophrenia.