Circulating neutrophil-to-lymphocyte ratio at admission predicts the long-term outcome in acute traumatic cervical spinal cord injury patients
Circulating neutrophil-to-lymphocyte ratio at admission predicts the long-term outcome in acute traumatic cervical spinal cord injury patients
复制标题
入院时循环中性粒细胞与淋巴细胞的比率可预测急性创伤性颈脊髓损伤患者的长期结果
DOI：
10.1186/s12891-020-03556-z
复制
发表时间：
2020-08-15
影响因子：
2.3
通讯作者：
Xie, Rong
中科院分区：
文献类型：
--
作者：
Zhao, Jian-Lan;Lai, Song-Tao;Xie, Rong
中性粒细胞/淋巴细胞比率(NLR)对急性颈髓损伤(TSCI)患者预后的预测价值目前国内外鲜有报道。方法采用单中心回顾性队列研究方法，评价急性颈髓损伤患者外周血中NLR的预后价值。纳入复旦大学华山医院2008-12/2018-05收治的急性颈椎病患者，发病6h内。采用美国脊柱损伤协会损伤评定量表(AIS)对TSCI患者的预后进行评估。6个月预后分为预后不良组(AISA~C)和预后良好组(AISD、E)。进行单变量和多变量分析以评估6个月结局的独立预测因素。建立两个基于入院特征的预测模型来评估NLR的预后价值。用曲线下面积评价预测模型的判别能力。多因素分析显示，年龄、入院时AIS分级、NLR(p
BackgroundThe prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome of acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout the world.MethodsWe performed a single-center retrospective cohort study to evaluate the prognostic value of NLR from peripheral whole blood count in patients with acute cervical tSCI. Patients within 6h of acute cervical tSCI treated between Dec 2008 and May 2018 in Huashan Hospital of Fudan University were enrolled. Outcomes of patients with tSCI were assessed using American spinal injury association Impairment Scale (AIS). 6-month outcomes were dichotomized into poor outcome group (AIS A to C) and good outcome group (AIS D and E). Uni- and multivariate analyses were performed to assess the independent predictors of 6-month outcome. Two prediction models based on admission characteristics were built to evaluate the prognostic value of NLR. The discriminative ability of predictive models was evaluated using the area under the curve (AUC).ResultsA total of 377 patients were identified from our single center in China PR. Multivariate analysis showed that age, AIS grade at admission, NLR (p