Insulin Administration Acutely Decreases Vaspin Serum Concentrations in Humans
Insulin Administration Acutely Decreases Vaspin Serum Concentrations in Humans
复制标题
注射胰岛素会急剧降低人体 Vaspin 血清浓度
DOI：
10.1159/000348836
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发表时间：
2013
期刊：
影响因子：
3.6
通讯作者：
Blüher M
中科院分区：
文献类型：
--
作者：
Kovacs P;Miehle K;Sandner B;Stumvoll M;Blüher M
有人假设，胰岛素可能调节与膳食有关的vaspin血清浓度的每日变化。因此，我们调查了胰岛素是否会影响人类的血清vaspin水平。采用双抗体夹心ELISA法测定10例健康体检者血清Vaspin浓度，并进行胰岛素耐量试验(ITT)，以评价垂体ACTH和生长激素储备情况。在隔夜禁食后08：00开始胰岛素注射，胰岛素剂量为0.15IU/kg体重(Actraid™)。分别于给药后-15、0、15、30、60、90、120分钟采血。给药后15min，血清vaspin浓度下降19±6%，60min继续下降42±12%，120min恢复到初始值的88±7%。我们的数据表明，与进餐有关的血清vaspin浓度的变化可能是由胰岛素介导的。
It has been hypothesized that insulin might mediate meal-related diurnal variation in vaspin serum concentrations. We therefore investigated whether insulin affects serum vaspin levels in humans. Vaspin serum concentrations were determined by ELISA in 10 healthy individuals, who underwent an insulin tolerance test (ITT) for the evaluation of pituitary ACTH and growth hormone reserve. The ITTs were started 08: 00 am after an overnight fast with a bolus iv insulin dose of 0.15 IU/kg body weight (Actrapid™). Blood samples were taken at-15, 0, 15, 30, 60, 90, and 120 min after insulin administration. 15 min after insulin administration, vaspin serum concentrations decreased by 19±6%, continued to decrease by 42±12% at 60 min and returned to 88±7% of initial values 120 min after insulin administration. Our data suggest that meal-related changes in serum vaspin concentrations might be mediated by insulin.
DOI：
10.1073/pnas.0504703102
发表时间：
2005-07-26
影响因子：
11.1
作者：
Hida, K;Wada, J;Kanwar, YS
通讯作者：
Kanwar, YS