Regulation of the expression of adhesion molecules by human synoviocytes.
Regulation of the expression of adhesion molecules by human synoviocytes.
复制标题
人类滑膜细胞粘附分子表达的调节。
DOI：
10.1016/0049-0172(92)90026-a
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发表时间：
1992
影响因子：
5
通讯作者：
Lipsky,PE
中科院分区：
文献类型：
--
作者：
Lindsley,HB;Smith,DD;Davis,LS;Koch,AE;Lipsky,PE
The capacity of synoviocytes to participate in inflammatory responses may be altered by the cytokine-enhanced expression of adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1). To examine this possibility, the ability of selected cytokines to enhance ICAM-1 expression was examined. The data indicated that each of these cytokines (interleukin-1β > tumor necrosis factor-α, interferon-γ ⪢ interleukin-6) can up-regulate synoviocyte ICAM-1 expression. This can potentially increase the ability of these cells to interact with infiltrating inflammatory cells, thereby propagating immunologically mediated inflammation such as occurs in rheumatoid synovitis.
