The investigation of K-complex and vertex sharp wave activity in response to mid-inspiratory occlusions and complete obstructions to breathing during NREM sleep
The investigation of K-complex and vertex sharp wave activity in response to mid-inspiratory occlusions and complete obstructions to breathing during NREM sleep
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DOI：
10.1093/sleep/24.1.81
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发表时间：
2001-02-01
期刊：
影响因子：
5.6
通讯作者：
Trinder, J
中科院分区：
文献类型：
--
作者：
Gora, J;Colrain, IM;Trinder, J
研究目的：确定对吸气中期阻塞的皮层反应是否可以用作睡眠期间对阻塞事件的皮层反应的模型;并确定顶点尖波（VSW）和K复合波是否是分别对第2阶段睡眠事件相关电位的N350和N550分量的唯一贡献者。设计：两种类型的呼吸刺激被用来引起诱发电位反应在第2阶段NREM睡眠。这些是吸气中期阻塞和完全呼吸阻塞。试验根据诱发的阶段性反应的类型进行分组;孤立的K波群（KC），与K波群相关的VSW（VSW/KC），孤立的VSW和无诱发反应（其他）。诱发反应分别在这些category.Setting平均：数据收集在大学的墨尔本Sleep Laboratory.Participants：六个年轻的健康男性成年人，干预措施：N/A测量和结果：数据记录从29头皮网站引用链接的耳朵。还记录面罩压力（Pm）和气流。胸内压，如Pm所示，在完全阻塞后比短暂阻塞后达到更负的水平。然而，这两种类型的呼吸刺激引起的两个晚潜伏期成分。虽然潜伏期在两种呼吸条件下的变化与胸内压力上升时间差异一致，但这些成分的激发特征和地形分布在两种类型的刺激中没有变化。此外，N350只存在于平均值为这些类别，包括VSW，而N550只存在于这些类别中，包含K-complex.Conclusions：中期吸气闭塞可用作阻塞事件的模型。VSW专门为N350组件做出贡献。而K-络合物仅贡献于N550组分。
Study Objectives: To determine whether the cortical response to mid-inspiratory occlusions can be used as a model of the cortical response to obstructive events during sleep; and to determine whether the vertex sharp wave (VSW) and K-complex are exclusive contributors to the N350 and N550 components respectively of the stage 2 sleep event-related potential.Design: Two types of respiratory stimuli were used to elicit evoked potential responses during stage 2 NREM sleep. These were mid-inspiratory occlusions and complete breath obstructions. Trials were grouped according to the type of phasic response elicited; isolated K-complex (KC), VSW associated with a K-complex (VSW/KC), isolated VSW, and no evoked response (other). Evoked responses were averaged separately within these categories.Setting: Data were collected in the University of Melbourne Sleep Laboratory.Participants: Six young healthy male adults,Interventions: N/AMeasurements and Results: Data were recorded from 29 scalp sites referenced to linked ears. Mask pressure (Pm) and airflow were also recorded. Intra-thoracic pressure, as indicated by Pm, reached a more negative level following complete obstructions than brief occlusions. However, both types of respiratory stimuli elicited the two late latency components. Although latency varied across the two respiratory conditions in a manner consistent with the intra-thoracic pressure rise time differences, the elicitation characteristics and topographic distribution of these components did not vary across the two types of stimuli. In addition, an N350 was only present in the average for those categories that included VSWs, while an N550 was only present in those categories that contained K-complexes.Conclusions: Mid-inspiratory occlusions can be used as a model of obstructive events. VSWs contribute exclusively to the N350 component. while K-complexes contribute exclusively to the N550 component.