DNA minor groove interactions and the biological activity of 2,5-bis-[4-(N-alkylamidino)phenyl] furans
DNA minor groove interactions and the biological activity of 2,5-bis-[4-(N-alkylamidino)phenyl] furans
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DOI：
10.1016/s0960-894x(00)00511-4
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发表时间：
2000-12-04
影响因子：
2.7
通讯作者：
Neidle, S
中科院分区：
文献类型：
--
作者：
Simpson, IJ;Lee, M;Neidle, S
2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against Pneumocystis carinii and also show cytotoxicity against several tumour cell lines. These activities are correlated with DNA-binding abilities; the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG) is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.
