Preserving the Self: The Process of Decision Making About Hereditary Breast Cancer and Ovarian Cancer Risk Reduction
Preserving the Self: The Process of Decision Making About Hereditary Breast Cancer and Ovarian Cancer Risk Reduction
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DOI：
10.1177/1049732310387798
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发表时间：
2011-04-01
影响因子：
3.2
通讯作者：
Rodney, Patricia
中科院分区：
文献类型：
--
作者：
Howard, A. Fuchsia;Balneaves, Lynda G.;Rodney, Patricia
携带BRCA 1或BRCA 2（BRCA 1/2）基因突变的女性患乳腺癌的终生风险高达88%，患卵巢癌的终生风险高达65%。解决这些风险的策略包括癌症筛查和降低风险的手术（即，乳房切除术和输卵管卵巢切除术）。我们对22名BRCA 1/2突变携带者进行了一项扎根理论研究，以了解女性如何对这些降低风险的策略做出决定。在参与者的描述中，保护自我是最重要的决策过程。这一过程是由上下文条件，包括卫生服务的特点，遗传性乳腺癌和卵巢癌风险降低的决定，性别角色的性质，以及妇女的感知接近癌症。这些妇女参与了五种决策风格，其特点是使用特定的决策方法。这些发现提供了理论见解，可以为BRCA 1/2携带者提供决策支持。
Women who carry BRCA1 or BRCA2 (BRCA1/2) gene mutations have up to an 88% lifetime risk of breast cancer and up to a 65% lifetime risk of ovarian cancer. Strategies to address these risks include cancer screening and risk-reducing surgery (i.e., mastectomy and salpingo-oophorectomy). We conducted a grounded theory study with 22 BRCA1/2 mutation-carrier women to understand how women make decisions about these risk-reducing strategies. Preserving the self was the overarching decision-making process evident in the participants' descriptions. This process was shaped by contextual conditions including the characteristics of health services, the nature of hereditary breast and ovarian cancer risk-reduction decisions, gendered roles, and the women's perceived proximity to cancer. The women engaged in five decision-making styles, and these were characterized by the use of specific decision-making approaches. These findings provide theoretical insights that could inform the provision of decisional support to BRCA1/2 carriers.