Oral fluid results compared to self reports of recent cocaine and heroin use by methadone maintenance patients
Oral fluid results compared to self reports of recent cocaine and heroin use by methadone maintenance patients
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DOI：
10.1016/j.forsciint.2011.01.046
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发表时间：
2012-02-10
影响因子：
2.2
通讯作者：
Cone, Edward J.
中科院分区：
文献类型：
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作者：
Cone, Edward J.
简介：虽然非法药物使用的自我报告可能不可靠，但这些信息经常被国家药物调查和药物治疗计划中的顾问收集和依赖。在这些项目中增加口腔液检测将提供近期药物使用的客观信息。目的：本研究的目的是比较口腔液检测可卡因、苯甲酰芽子碱、6-乙酰吗啡、吗啡、可待因和6-乙酰可待因与门诊美沙酮治疗项目中患者近期使用可卡因和海洛因的自我报告。患者（n = 400）提供了一个口腔液标本，并完成了一个简短的问卷调查非法药物使用在过去的七天。用Intercept（R）口腔液体收集装置收集口腔液体。采用液相色谱-串联质谱法，通过经验证的测定法分析口腔液。如果符合所有鉴别标准且其浓度（ng/ mL）>= LOQ，则确认存在分析物（可卡因，0.4;苯甲酰芽子碱，0.4;吗啡，2;可待因，2; 6-乙酰吗啡，0.4;和6-乙酰可待因，1）。从400名美沙酮维持治疗的患者中收集的口腔液样本的分析显示，大多数（95%）承认最近使用可卡因的受试者被证实为阳性，而在过去七天内曾吸食海洛英的人士，则有略多于百分之五十被证实呈阳性反应。对于那些否认最近使用可卡因和海洛因的患者，约30%是可卡因阳性，14%是阳性的海洛因。结论：口腔液测试提供了一个客观的手段，验证最近的药物使用和评估的患者在治疗物质使用障碍。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Introduction: Although self reports of illicit drug use may not be reliable, this information is frequently collected and relied upon by national drug surveys and by counselors in drug treatment programs. The addition of oral fluid testing to these programs would provide objective information on recent drug use.Aim: The goal of this study was to compare oral fluid tests for cocaine, benzoylecgonine, 6-acetylmorphine, morphine, codeine and 6-acetylcodeine to self reports of recent cocaine and heroin use by patients in an outpatient methadone treatment program.Methods: Patients (n = 400) provided an oral fluid specimen and completed a short questionnaire on illicit drug use over the last seven days. Oral fluid was collected with the Intercept (R) Oral Fluid Collection device. Oral fluid was analyzed by a validated assay using liquid chromatography coupled with tandem mass spectrometry. The presence of an analyte was confirmed if all identification criteria were met and its concentration (ng/ mL) was >= LOQ (cocaine, 0.4; benzoylecgonine, 0.4; morphine, 2; codeine, 2; 6-acetylmorphine, 0.4; and 6-acetylcodeine, 1).Results: Analyses of oral fluid specimens collected from the 400 methadone maintained patients revealed that a majority (95%) of subjects who admitted to recent cocaine use were confirmed positive, whereas slightly more than 50% were confirmed positive who admitted to heroin over the last seven days. For those patients who denied recent cocaine and heroin use, approximately 30% were positive for cocaine and 14% were positive for heroin.Conclusion: Oral fluid testing provides an objective means of verifying recent drug use and for assessment of patients in treatment for substance use disorders. (C) 2011 Elsevier Ireland Ltd. All rights reserved.