Microparticles as Biomarkers of Blood Coagulation in Cancer.
Microparticles as Biomarkers of Blood Coagulation in Cancer.
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微粒作为癌症血液凝结的生物标志物。
DOI：
10.4137/bic.s30347
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Shimizu M
中科院分区：
文献类型：
--
作者：
Nomura S;Niki M;Nisizawa T;Tamaki T;Shimizu M
癌症与高凝血病和血栓形成风险增加有关。这会对患者的发病率和死亡率产生负面影响。癌症也经常并发静脉血栓栓塞（VTE）。肿瘤源性组织因子（TF）承载微粒（MPs）与恶性肿瘤静脉血栓栓塞事件相关。MPs是许多不同类型的细胞在细胞活化或凋亡时，通过胞外出芽从质膜中释放出来的小膜囊泡。MPs也可能通过促凝磷脂的表达参与临床疾病。检测肿瘤患者中表达tf的MPs可能具有临床价值。在肺癌和乳腺癌患者中，MPs诱导转移和血管生成，可能是血管并发症的指标。此外，在各种类型的癌症患者中，MPs具有粘附蛋白并结合靶细胞以促进癌症的进展或转移。肿瘤细胞过表达TF与肿瘤进展密切相关，而肿瘤细胞中表达TF的MPs的脱落与癌症的遗传状态相关。因此，表达tf的MPs是癌症患者静脉血栓栓塞并发症预防和治疗中需要考虑的重要标志物。
Cancer is associated with hypercoagulopathy and increased risk of thrombosis. This negatively influences patient morbidity and mortality. Cancer is also frequently complicated by the development of venous thromboembolism (VTE). Tumor-derived tissue factor (TF)-bearing microparticles (MPs) are associated with VTE events in malignancy. MPs are small membrane vesicles released from many different cell types by exocytic budding of the plasma membrane in response to cellular activation or apoptosis. MPs may also be involved in clinical diseases through expression of procoagulative phospholipids. The detection of TF-expressing MPs in cancer patients may be clinically useful. In lung and breast cancer patients, MPs induce metastasis and angiogenesis and may be indicators of vascular complications. Additionally, MPs in patients with various types of cancer possess adhesion proteins and bind target cells to promoting cancer progression or metastasis. Overexpression of TF by cancer cells is closely associated with tumor progression, and shedding of TF-expressing MPs by cancer cells correlates with the genetic status of cancer. Consequently, TF-expressing MPs represent important markers to consider in the prevention of and therapy for VTE complications in cancer patients.