ENDOGENOUS Na/K-ATPase INHIBITORS IN PATIENTS WITH PREECLAMPSIA
ENDOGENOUS Na/K-ATPase INHIBITORS IN PATIENTS WITH PREECLAMPSIA
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DOI：
10.1170/t755
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发表时间：
2006-01-01
影响因子：
1.6
通讯作者：
Bagrov, A. Y.
中科院分区：
文献类型：
--
作者：
Averina, I. V.;Tapilskaya, N. I.;Bagrov, A. Y.
尽管先兆子痫（PE）是孕产妇和胎儿死亡的主要原因，但其发病机制尚不完全清楚。洋地黄类强心类固醇 (CTS) 被认为与 PE 的病理生理学有关，临床观察表明，DIGIBIND（一种与 CTS 结合的地高辛抗体）可降低 PE 患者的血压。最近，我们报道了严重 PE 患者血浆中海蟾蜍配基 (MBG)（一种血管收缩剂 CTS）的水平增加了四倍。在本研究中，我们测试了抗MBG、抗哇巴因抗体或DIGIBIND是否可以逆转轻度PE患者（血压，149 +/- 3/93 +/- 3 mm Hg；年龄，28 +/- 2岁；胎龄，37 +/- 1周）的红细胞Na/K-ATP酶（NKA）抑制。 PE 的发生与血浆 MBG 水平的两倍升高相关（1.58 +/- 0.15 vs. 0.80 +/- 0.11 nmol/L；P
Although preeclampsia (PE) is a major cause of maternal and fetal mortality, its pathogenesis is not fully understood. Digitalis-like cardiotonic steroids (CTS) are believed to be involved in the pathophysiology of PE, as illustrated by clinical observations that DIGIBIND, a digoxin antibody which binds CTS, lowers blood pressure in PE. Recently we reported that plasma levels of marinobufagenin (MBG), a vasoconstrictor CTS, are increased fourfold in patients with severe PE. In the present study, we tested whether anti-MBG, or anti-ouabain antibodies, or DIGIBIND can reverse inhibition of erythrocyte Na/K-ATPase (NKA) from patients with mild PE (blood pressure, 149 +/- 3/93 +/- 3 mm Hg; age, 28 +/- 2 years; gestational age, 37 +/- 1 weeks). Development of PE was associated with twofold rise in plasma MBG levels (1.58 +/- 0.15 vs. 0.80 +/- 0.11 nmol/L; P