AUTONOMIC CARDIAC CONTROL .2. NONINVASIVE INDEXES AND BASAL RESPONSE AS REVEALED BY AUTONOMIC BLOCKADES
AUTONOMIC CARDIAC CONTROL .2. NONINVASIVE INDEXES AND BASAL RESPONSE AS REVEALED BY AUTONOMIC BLOCKADES
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DOI：
10.1111/j.1469-8986.1994.tb02351.x
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发表时间：
1994-11-01
期刊：
影响因子：
3.7
通讯作者：
FIELDSTONE, A
中科院分区：
文献类型：
--
作者：
CACIOPPO, JT;BERNTSON, GG;FIELDSTONE, A
在三种药物条件（生理盐水、硫酸阿托品、美托洛尔）下，连续三天测量女性受试者的心脏周期、收缩时间间期、低频和高频心脏周期变异性、血压和呼吸。根据输注前基线记录，输注生理盐水、美托洛尔（14 mg）或硫酸阿托品（2 mg）15 min（采用双盲程序）。记录在输注后基线期间和对直立性应激源（站立与坐姿）的反应中进行。在美托洛尔疗程结束时，输注硫酸阿托品，并在输注后监测反应（即，双阻滞）基线和直立性应激期间。对阻滞数据的分析表明，射血前期（PEP）反映了交感神经对心脏的影响，而不是迷走神经对心脏的影响，高频（HF，0.12-0.40 Hz）心率变异性（呼吸性窦性心律失常）反映了迷走神经对心脏的影响，而不是交感神经对心脏的影响。没有其他措施提供了一个具体的指数紧张性交感神经或迷走神经激活的心脏。生理盐水下的输注后PEP预测输注后心脏交感神经激活的个体差异，而生理盐水下的输注后心脏周期（但不是HF变异性）预测输注后心脏迷走神经激活的个体差异。
Heart period, systolic time intervals, low and high frequency heart period variability, blood pressure, and respiration were measured in female subjects under three drug conditions (saline, atropine sulfate, metoprolol) while sitting and standing on three consecutive days. Following preinfusion baseline recordings, saline, metoprolol (14 mg), or atropine sulfate (2 mg) was infused for 15 min (by using a double-blind procedure). Recordings were taken during a postinfusion baseline and in response to an orthostatic stressor (standing versus sitting postures). At the end of the metoprolol session, atropine sulfate was infused and responses were monitored during the postinfusion (i.e., double blockade) baseline and during orthostatic stressor. Analyses of the blockade data revealed that the preejection period (PEP) reflected sympathetic but not vagal influences on the heart, and high frequency (HF, 0.12-0.40 Hz) heart rate variability (respiratory sinus arrhythmia) reflected vagal but not sympathetic influences on the heart. No other measure provided a specific index of the tonic sympathetic or vagal activation of the heart. Postinfusion PEP under saline predicted individual differences in postinfusion cardiac sympathetic activation, whereas postinfusion heart period (but not HF variability) under saline predicted individual differences in postinfusion cardiac vagal activation.