GENETIC ALTERATION OF THE C-MYC PROTOONCOGENE (MYC) IN HUMAN PRIMARY BREAST CARCINOMAS
GENETIC ALTERATION OF THE C-MYC PROTOONCOGENE (MYC) IN HUMAN PRIMARY BREAST CARCINOMAS
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DOI：
10.1073/pnas.83.13.4834
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发表时间：
1986-07-01
影响因子：
11.1
通讯作者：
CALLAHAN, R
中科院分区：
文献类型：
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作者：
ESCOT, C;THEILLET, C;CALLAHAN, R
我们研究了 121 例人类原发性乳腺癌的 c-myc 位点 (MYC) 的基因组结构。观察到两种类型的改变：(i) c-myc 原癌基因似乎在 38 个 (32%) 的癌 DNA 中扩增了 2 至 15 倍，(ii) 在 5 个原发性乳腺癌 DNA 中检测到不同大小的非种系 c-myc 相关片段。除三个例外，所有含有 c-myc 基因座基因改变的肿瘤都是浸润性导管癌。在 50 岁以上的患者与 c-myc 基因改变的存在之间观察到显着相关性 (P < 0.02)。在检查的 14 例乳腺癌中，有 10 例观察到 c-myc RNA 水平升高。这 10 个肿瘤中有 6 个的 c-myc 基因发生了基因改变。 c-myc 基因改变的频率及其与年龄的相关性表明它可能在乳腺癌的发展中发挥作用。
We have studied the genomic organization of the c-myc locus (MYC) from 121 human primary breast carcinomas. Two types of alterations were observed: (i) the c-myc protooncogene appeared to be amplified 2- to 15-fold in 38 (32%) of the carcinoma DNAs and (ii) a non-germ-line c-myc-related fragment of variable size was detected in 5 primary breast carcinoma DNAs. With three exceptions, all the tumors containing a genetic alteration of the c-myc locus were invasive ductal carcinomas. A significant correlation (P < 0.02) was observed between patients more than 50 years old and the presence of a genetically altered c-myc. Enhanced levels of c-myc RNA were observed in 10 of 14 breast carcinomas examined. The c-myc gene was genetically altered in 6 of these 10 tumors. The frequency with which the c-myc gene is altered and its correlation with age suggest that it may play a role in the development of breast carcinomas.