Consumption of animal products, olive oil and dietary fat and results from the Belgian case-control study on bladder cancer risk
Consumption of animal products, olive oil and dietary fat and results from the Belgian case-control study on bladder cancer risk
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DOI：
10.1016/j.ejca.2010.09.027
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发表时间：
2011-02-01
影响因子：
8.4
通讯作者：
Zeegers, Maurice P.
中科院分区：
文献类型：
--
作者：
Brinkman, Maree T.;Buntinx, Frank;Zeegers, Maurice P.
目的：西方饮食通常含有大量来自动物产品的饱和脂肪，这与膀胱癌的风险增加有关。虽然橄榄油，地中海饮食中的主要脂肪，与许多健康益处有关，但它在膀胱癌病因中的作用仍然未知。因此，我们研究了动物产品、橄榄油和其他主要膳食脂肪的摄入对膀胱癌风险的影响。方法：收集参加比利时膀胱癌病例-对照研究的200例患者和386例对照者的饮食资料。我们使用无条件逻辑回归，通过比较病例和对照组之间最高和最低的摄入量，计算比值比（ORs）和95%置信区间（CIs）。对年龄、性别、吸烟特征、职业暴露和卡路里摄入量进行了调整。结果：橄榄油摄入量与膀胱癌之间存在统计学上显著的负相关关系，符合线性剂量-反应关系：中位数与最低位数（OR: 0.62; 95% CI: 0.39-0.99），最高位数与最低位数（OR: 0.47; 95% CI: 0.28-0.78； p趋势= 0.002）。我们还观察到，奶酪摄入量最高的人群患膀胱癌的几率比摄入量最低的人群高（OR: 1.53; 95% CI: 0.95-2.46; p-trend = 0.08）。没有发现任何其他来源或类型的膳食脂肪的潜在关联。结论：我们观察到橄榄油有保护作用的证据，以及大量摄入奶酪可能增加膀胱癌风险的证据。我们的结果需要进一步的调查和其他研究的证实。(C) 2010 Elsevier Ltd.版权所有。
Aim: The Western diet typically consists of high levels of saturated fat from animal products and has been associated with an increased risk of bladder cancer. Whilst olive oil, the predominant fat in the Mediterranean diet, has been associated with many health benefits its role in bladder cancer aetiology is still unknown. Therefore, we investigated the effect of intake of animal products, olive oil and other major dietary fats on bladder cancer risk.Methods: Dietary data were collected from 200 cases and 386 controls participating in a Belgian case-control study on bladder cancer. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) by comparing the highest with the lowest tertiles of intake between cases and controls using unconditional logistic regression. Adjustment was made for age, sex, smoking characteristics, occupational exposures and calorie intake.Results: There was a statistically significant inverse association between olive oil intake and bladder cancer consistent with a linear dose-response relationship: middle versus the lowest tertile (OR: 0.62; 95% CI: 0.39-0.99) and the highest versus the lowest tertile (OR: 0.47; 95% CI: 0.28-0.78; p-trend = 0.002). We also observed borderline statistically significant increased odds of bladder cancer for the highest versus the lowest intake of cheese (OR: 1.53; 95% CI: 0.95-2.46; p-trend = 0.08). No potential associations were detected for any other source or type of dietary fat.Conclusion: We observed evidence for a protective effect by olive oil and a possible increased risk of bladder cancer associated with a high intake of cheese. Our results require further investigation and confirmation by other studies. (C) 2010 Elsevier Ltd. All rights reserved.