EFFECTS OF SPLENECTOMY ON SERUM-LIPIDS AND EXPERIMENTAL ATHEROSCLEROSIS
EFFECTS OF SPLENECTOMY ON SERUM-LIPIDS AND EXPERIMENTAL ATHEROSCLEROSIS
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DOI：
10.1177/000331978803900602
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发表时间：
1988-06-01
期刊：
影响因子：
2.8
通讯作者：
KUZUYA, F
中科院分区：
文献类型：
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作者：
ASAI, K;KUZUYA, M;KUZUYA, F
作者研究了脾切除术对血液病患者、家兔和实验性动脉粥样硬化的胆固醇喂养家兔血脂的影响。测定脾功能亢进患者脾切除术前后血清胆固醇水平。同时测定脾切除组（Spx组，n = 19）和假手术组（Sham组，n = 14）手术前后的血脂水平。然后将家兔分为四个亚组：胆固醇组（12只）和假手术组（9只），正常饲料组（7只）和假手术组（5只）。Spx-C和Sham-C兔饲喂1%胆固醇饲料，Spx-N和Sham-N兔饲喂正常饲料，持续12周。患者术前血清胆固醇水平较低，脾切除术后血清胆固醇显著升高。在家兔中，与Sham-C组相比，Spx-C组的血清胆固醇、甘油三酯和磷脂水平显著较高，而高密度脂蛋白胆固醇水平较低。Spx-C组主动脉斑块面积百分比有高于Sham-C组的趋势。另一方面，Spx-N组和Sham-N组在12周期间的血清脂质没有差异。认为Spx-C组动脉粥样硬化恶化主要是由于高脂血症增加。他们的研究结果表明，脾脏在脂质代谢中可能发挥作用，特别是存在一种脾因子，可导致脾功能亢进时的低胆固醇血症，并可抑制高脂血症。
The authors examined the effects of splenectomy on serum lipids in patients with hematologic disese, in rabbits, and also in cholesterol-fed rabbits with experimental atherosclerosis. Serum cholesterol was determined in patients with hypersplenism before and after splenectomy. Meanwhile serum lipids were determined in two groups of rabbits: splenectomy group (Spx group, n = 19), and sham operation group (Sham group, n = 14) before and after the operation. Then the rabbits were divided into four subgroups: cholesterol-fed groups.sbd.Spx-C (n = 12) and Sham-C (n = 9), and normal-chow-fed groups.sbd.Spx-N (n =7) and Sham-N (n = 5). The Spx-C and the Sham-C rabbits were fed 1% cholesterol diet and the Spx-N and the Sham-N rabbits were fed normal chow for twelve weeks. In patients preoperative serum cholesterol levels were low, and significant increase in serum cholesterol was observed following splenectomy. In rabbits, the Spx-C group showed significantly higher levels of serum cholesterol, triglycerides, and phospholipids in contrast to lower levels of high density lipoprotein cholesterol, as compared with the Sham-C group. The percentage of aortic plaque area in the Spx-C group tended to be higher than that in the Sham-C group. On the other hand, the Spx-N and the Sham-N group showed no difference in serum lipids during twelve weeks. The worsening of atherosclerosis in the Spx-C group was considered to be mainly due to an enhanced hyperlipidemia. Their results suggest a possible role of the spleen in lipid metabolism, in particular the existence of a splenic factor that can cause hypocholesterolemia in hypersplenism and can suppress hyperlipidemia.