PASSIVE SMOKING AT WORK - BIOCHEMICAL AND BIOLOGICAL MEASURES OF EXPOSURE TO ENVIRONMENTAL TOBACCO-SMOKE
PASSIVE SMOKING AT WORK - BIOCHEMICAL AND BIOLOGICAL MEASURES OF EXPOSURE TO ENVIRONMENTAL TOBACCO-SMOKE
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DOI：
10.1007/bf00405277
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发表时间：
1987-01-01
影响因子：
3
通讯作者：
EINISTO, P
中科院分区：
文献类型：
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作者：
HUSGAFVELPURSIAINEN, K;SORSA, M;EINISTO, P
烟草烟雾摄入的几个生化和生物学措施被用来评估暴露的餐厅人员与积极吸烟者和非暴露的非吸烟者相比，环境烟草烟雾。与非暴露组（n = 20）相比，吸烟组（n = 22）的所有测量参数-血浆中的碳氧血红蛋白（COHb）、硫氰酸盐（SCN）和可替宁、尿液中的可替宁和致突变性、总白色血细胞计数（WBC）和培养淋巴细胞中的姐妹染色单体交换（SCE）频率均显著升高。与工作相关的被动暴露（n = 27）在血浆中的可替宁值中最为明显（被动吸烟者的平均P-cot为10 ng/ml，未暴露者为5.2 ng/ml）和尿液（被动吸烟者的平均U-cot为56 ng/ml，未接触者为8.3 ng/ml），但硫氰酸盐水平也显著增加，（被动吸烟者的平均P-SNC为58 μ mol/l，而非暴露者为46 μ mol/l），作为总白细胞计数的初步发现（在被动吸烟者中为8.0 × 10 - 6），109/l对6.8 ×109/l（未暴露）。结果表明，环境烟草烟雾可能是一种职业健康危害。
Several biochemical and biological measures of tobacco smoke intake were used to evaluate exposure of restaurant personnel to environmental tobacco smoke as compared with active smokers and non-exposed non-smokers. All of the measured parameters-carboxyhaemoglobin (COHb), thiocyanate (SCN) and cotinine in plasma, cotinine and mutagenicity in urine, total white blood cell count (WBC), and sister chromatid exchange (SCE) frequency in cultured lymphocytes-were significantly elevated in the smoker group (n = 22) compared to the non-exposed group (n = 20). Work-related passive exposure (n = 27) was seen most clearly in the cotinine values, both from plasma (mean P-cot in passive smokers 10 ng/ml vs. 5.2 ng/ml in non-exposed) and from urine (mean U-cot in passive smokers 56 ng/ml vs. 8.3 ng/ml in non-exposed), but significant increases were also seen in the thiocyanate levels (mean P-SNC in passive smokers 58 .mu.mol/l vs 46 .mu.mol/l in non-exposed) and, as a preliminary finding in total leucocyte count (in passive smokers 8.0 .times. 109/l vs 6.8 .times. 109/l in non-exposed). The results demonstrate that environmental tobacco smoke may be an occupational health hazard.