1ST MEIOTIC DIVISION ABNORMALITIES IN HUMAN OOCYTES - MECHANISM OF TRISOMY FORMATION
1ST MEIOTIC DIVISION ABNORMALITIES IN HUMAN OOCYTES - MECHANISM OF TRISOMY FORMATION
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DOI：
10.1159/000133631
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发表时间：
1994-01-01
期刊：
影响因子：
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通讯作者：
BAIRD, DT
中科院分区：
文献类型：
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作者：
ANGELL, RR;XIAN, J;BAIRD, DT
三体是人类最常见的一种染色体异常类型，对人类病理学的许多方面都有相当大的影响。它最常见的发生方式是母体减数分裂I期的“不分离”，但其潜在的形成机制仍不清楚。对100个处于第二次减数分裂中期的单倍体卵母细胞的分析表明，受精后与三倍体形成兼容的唯一类型的染色体异常是除了或取代整个染色体外，还存在单个染色单体。单染色体的形成机制被认为是在减数分裂后期的第一次单价体或二分体的早熟分裂。
Trisomy is the single most frequent type of chromosome abnormality in humans and has considerable impact on many aspects of human pathology. It arises most commonly through ''nondisjunction'' at maternal meiosis I, but the underlying mechanism of formation remains obscure. Analysis of 100 haploid oocytes at second meiotic metaphase shows that the only type of chromosome abnormality compatible with trisomy formation after fertilisation is the presence of single chromatids in addition to, or replacing, whole chromosomes. The mechanism resulting in the presence of single chromatids is considered to be precocious division of univalents or dyads at first meiotic anaphase.