Non-invasive electrical stimulation of peripheral nerves for the management of tremor.
Non-invasive electrical stimulation of peripheral nerves for the management of tremor.
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DOI：
10.1016/j.jns.2022.120195
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发表时间：
2022-04-15
影响因子：
4.4
通讯作者：
Delp, Scott
中科院分区：
文献类型：
--
作者：
Pascual-Valdunciel, Alejandro;Rajagopal, Apoorva;Pons, Jose L.;Delp, Scott
关键词：
特发性震颤和帕金森病患者的病理性震颤通常使用药物或神经外科干预措施进行治疗。人们普遍认识到需要新的治疗方法，以避免现有药物的副作用，并且不带来手术干预的风险。基于数十年的研究和工程发展，周围神经的无创电刺激已成为减少原发性震颤病理性震颤的安全有效的策略。本综述调查了外周电刺激 (PES) 文献，并总结了各种 PES 方法的有效性、安全性、临床可转化性和假设的震颤减少机制。该综述还提出了在评估新疗法的背景下评估震颤的指南，这些新疗法结合了临床医生评估、患者评估和新型运动传感技术的优势。该综述最后总结了 PES 的未来方向，包括扩大帕金森病患者的临床可及性，并利用大型家庭数据集来了解更多有关震颤生理学和治疗效果的信息，从而更好地描述震颤管理的状态并加速新疗法的发现。越来越多的证据表明，传入神经通路的非侵入性电刺激为病理性震颤的治疗提供了一种可行的新选择，其中一种特定的 PES 疗法已被批准用于处方和家庭使用，这表明 PES 可以与药物和神经外科干预措施一起考虑用于治疗震颤。
Pathological tremor in patients with essential tremor and Parkinson’s disease is typically treated using medication or neurosurgical interventions. There is a widely recognized need for new treatments that avoid the side effects of current medications and do not carry the risks of surgical interventions. Building on decades of research and engineering development, non-invasive electrical stimulation of peripheral nerves has emerged as a safe and effective strategy for reducing pathologic tremor in essential tremor. This review surveys the peripheral electrical stimulation (PES) literature and summarizes effectiveness, safety, clinical translatability, and hypothesized tremor-reduction mechanisms of various PES approaches. The review also proposes guidelines for assessing tremor in the context of evaluating new therapies that combine the strengths of clinician assessments, patient evaluations, and novel motion sensing technology. The review concludes with a summary of future directions for PES, including expanding clinical access for patients with Parkinson’s disease and leveraging large, at-home datasets to learn more about tremor physiology and treatment effect that will better characterize the state of tremor management and accelerate discovery of new therapies. Growing evidence suggests that non-invasive electrical stimulation of afferent neural pathways provides a viable new option for management of pathological tremor, with one specific PES therapy cleared for prescription and home use, suggesting that PES be considered along with medication and neurosurgical interventions for treatment of tremor.
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影响因子：
3.3
作者：
Dideriksen, Jakob L.;Muceli, Silvia;Farina, Dario
通讯作者：
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影响因子：
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作者：
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通讯作者：
Tintner, Ron
DOI：
10.1109/tnsre.2014.2328296
发表时间：
2015-05-01
影响因子：
4.9
作者：
Dosen, Strahinja;Muceli, Silvia;Farina, Dario
通讯作者：
Farina, Dario
脑代谢随着基本震颤受试者的纵向经态传入刺激而变化。
DOI：
10.5334/tohm.565
发表时间：
2020-12-16
期刊：
Tremor and other hyperkinetic movements (New York, N.Y.)
影响因子：
--
作者：
Barath AS;Rusheen AE;Min HK;Lee J;Ross E;Shin S;Loudermilk A;Wessel B;Lowe VJ;Lee KH;Blaha CD
通讯作者：
Blaha CD