Impact of obesity in intima media thickness' of carotid arteries
Impact of obesity in intima media thickness' of carotid arteries
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DOI：
10.1038/oby.2006.196
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发表时间：
2006-10-01
期刊：
影响因子：
6.9
通讯作者：
Zakopoulos, Nikos A.
中科院分区：
文献类型：
--
作者：
Kotsis, Vasilios T.;Stabouli, Stella V.;Zakopoulos, Nikos A.
目的：探讨颈动脉内膜中层厚度（IMT）的差异引起的BMI.研究方法和程序的差异：从3173例连续的受试者，谁被称为我们的高血压中心从1998年至2004年，进行了审查。考虑进行进一步分析的患者标准包括既往无或同时使用抗高血压药物，无可能升高血压（BP）的合并药物（例如，泼尼松），并且没有高血压继发原因的临床体征或实验室证据。根据NIH的肥胖标准，我们的人群被分为四组：体重不足，正常体重，超重和肥胖。所有受试者的BMI、颈内动脉平均IMT和24小时BP值均可用。年龄、性别和平均24小时BP值相匹配的四组536例受试者被纳入分析。肥胖组平均IMT显著高于正常体重组（p < 0.01）和体重不足组（p < 0.001）。超重组平均IMT显著高于正常体重组（p < 0.05）。此外，在肥胖受试者的多变量回归分析显示，空腹血糖是独立相关的IMT。讨论：肥胖可能是颈动脉粥样硬化的一个重要因素，至少有一些肥胖的影响是独立的BP水平。肥胖者空腹血糖水平可能在颈动脉粥样硬化中起重要作用。
Objective: To explore differences in intima media thickness (IMT) of the carotid arteries induced by differences in BMI.Research Methods and Procedures: Data from 3173 consecutive subjects, who were referred to our Hypertension Center from 1998 to 2004, were reviewed. Criteria for patients to be considered for further analysis included no past or concurrent antihypertensive medication, no concurrent medication with the potential to raise blood pressure (BP) (e.g., prednisone), and no clinical signs or laboratory evidence of secondary causes of hypertension. Our population was divided into four groups according to NIH criteria for obesity: underweight, normal weight, overweight, and obese. BMI, mean IMT of internal carotid arteries, and 24-hour BP values were available for all subjects. Five hundred thirty six subjects of the four groups, matched for age, gender, and mean 24-hour BP values, were included in the analysis.Results: Mean IMT of internal carotid arteries was increased with increasing BMI. Mean IMT was significantly higher in obese subjects compared with normal-weight (p < 0.01) and underweight (p < 0.001) subjects. Mean IMT was significantly higher in overweight subjects compared with normal-weight ones (p < 0.05). Furthermore, multivariate regression analysis in obese subjects revealed that fasting serum glucose was independently associated with IMT.Discussion: Obesity may be an important factor for carotid atherosclerosis, and at least some of the effects of obesity are independent of the BP levels. Fasting serum glucose levels in obese subjects may play an important role in carotid atherosclerosis.