Self-restrained regulation of stem cell niche activity by niche components in the Drosophila testis
Self-restrained regulation of stem cell niche activity by niche components in the Drosophila testis
复制标题
果蝇睾丸中的生态位成分对干细胞生态位活性的自我抑制调节
DOI：
10.1016/j.ydbio.2018.04.011
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发表时间：
2018
影响因子：
2.7
通讯作者：
Li ZH
中科院分区：
文献类型：
--
作者：
Xu Ran;Li Jing;Zhao Hang;Kong Ruiyan;Wei Min;Shi Lin;Bai Guang;Li Zhouhua;Li ZH
大多数（如果不是全部的话）干细胞存在于一个定义的微环境中，称为小生境。短程生态位信号必须被严格控制为仅在生态位内活跃，以维持干细胞自我更新与分化的适当平衡。然而，如何小生境组件限制本地化的小生境信号激活仍然在很大程度上未知。在这里，我们发现睾丸龛的囊肿干细胞（CySC）中的Thickveins（TcR，Dpp信号通路的I型受体）阻止龛外的Dpp信号激活。我们发现，TPPs功能作为Dpp陷阱/水槽空间抑制Dpp信号内的利基。这种通过TcP在CySC中对生态位活性的自我抑制调节独立于经典Dpp信号传导途径。我们的数据表明，生态位组件（CySC）在生态位活性的自我约束调节中的关键作用，这可能会揭示生态位活性调节的一般。
Most, if not all, stem cells reside in a defined microenvironment, called the niche. Short-ranged niche signal must be tightly controlled to be active only inside the niche to maintain the proper balance of stem cell self-renewal verse differentiation. However, how niche components restrict localized niche signal activation remains largely unknown. Here, we find that Thickveins (Tkv, a type I receptor of the Dpp signaling pathway) in cyst stem cells (CySCs) of the testis niche prevents Dpp signaling activation outside of the niche. We show that Tkv functions as Dpp trap/sink to spatially restrain Dpp signaling inside the niche. This self-restrained regulation of niche activity by Tkv in CySCs is independent of the canonical Dpp signaling pathway. Our data demonstrate the critical roles of niche components (CySCs) in the self-restrained regulation of niche activity, which could be shed light on niche activity regulation in general.