Clinical trial of cisplatin and intensive course 5-fluorouracil for the treatment of advanced colorectal cancer.
Clinical trial of cisplatin and intensive course 5-fluorouracil for the treatment of advanced colorectal cancer.
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顺铂联合强化疗程5-氟尿嘧啶治疗晚期结直肠癌的临床试验。
DOI：
10.1097/00000421-198606000-00004
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Rubin,J
中科院分区：
文献类型：
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作者：
O'Connell,MJ;Moertel,CG;Kvols,LK;Hahn,RG;Rubin,J
对37例晚期结直肠癌患者进行了5天顺铂联合负荷疗程5-氟尿嘧啶（5-FU）的临床试验。目的：34例未接受化疗的患者中有10例（29%）出现肿瘤应答。先前未治疗的患者的估计中位生存期为26周，从治疗开始测量。毒性主要包括白细胞减少、呕吐和可逆性肾功能不全。这种顺铂和强化疗程5-FU的组合在晚期结直肠癌患者中已显示出II期活性。目前正在进行一项对照试验，对该方案与全剂量单药5-FU进行前瞻性比较。
A clinical trial of 5-day Cisplatin combined with loading course 5-fluorouracil (5-FU) was conducted in 37 patients with advanced colorectal carcinoma. Objective tumor responses were seen in 10 of 34 patients (29%) who had not received prior chemotherapy. The estimated median survival for previously untreated patients is 26 weeks measured from the onset of therapy. Toxicity consisted primarily of leukopenia, vomiting, and reversible renal insufficiency. This combination of cisplatin and intensive course 5-FU has demonstrated Phase II activity in patients with advanced colorectal cancer. A controlled trial is now in progress to prospectively compare this regimen with full dose single agent 5-FU.