Changes in cortically induced rhythmic jaw movements after lesioning of the red nucleus in rats
Changes in cortically induced rhythmic jaw movements after lesioning of the red nucleus in rats
复制标题
DOI：
10.1016/j.brainres.2007.06.008
复制
发表时间：
2007-08
期刊：
影响因子：
2.9
通讯作者：
Y. Satoh;K. Ishizuka;T. Murakami
中科院分区：
文献类型：
--
作者：
Y. Satoh;K. Ishizuka;T. Murakami
我们研究红核（RN）病变是否可以改变有节奏的下颌运动。通过对两个皮质咀嚼区域（A 区：口面部运动皮层；P 区：岛叶皮层）的重复电刺激诱导有节奏的下颌运动。研究发现，在 RN 中施加电流造成的损伤会影响 A 区刺激引起的有节奏的下颌运动。诱发病变后，最大和最小下颌张开位置之间的距离较小。损伤后有节奏的下颌运动持续时间较短。相反，RN 的病变不会影响 P 区刺激引起的有节奏的下颌运动。接下来，将红藻氨酸（0.2μl，病变组）或磷酸盐缓冲盐水（0.2μl，对照组）注射到左侧RN中。注射三天后，通过重复电刺激 A 区诱导有节奏的下颌运动。病变组最大和最小张口位置之间的距离小于对照组。病变组的节律性下颌运动持续时间短于对照组。这些结果表明 RN 参与了 A 区刺激引起的下颌运动的改变。
We study whether the red nucleus (RN) lesion can modify rhythmic jaw movements. Rhythmic jaw movements were induced by repetitive electrical stimulation of the two cortical masticatory areas (area A: the orofacial motor cortex; area P: the insular cortex). Lesions made by applied electric current in the RN were found to influence the rhythmic jaw movements induced by stimulation of A-area. The distance between the maximum and minimum jaw-opening positions was less after the lesions were induced. The duration of rhythmic jaw movements was shorter after lesioning. In contrast, lesions of the RN did not influence rhythmic jaw movements induced by stimulation of the P-area. Next, kainic acid (0.2 μl, lesion group) or phosphate-buffered saline (0.2 μl, control group) was injected into the left RN. Three days after injection, rhythmic jaw movements were induced by repetitive electrical stimulation of the A-area. The distance between the maximum and minimum jaw-opening positions in the lesion group was smaller than in the control group. The rhythmic jaw movements of the lesion group had shorter duration than the control group. These results suggest that the RN is involved in the modification of jaw movements induced by stimulation of the A-area.