Feeding and activity induced by orexin A in the lateral hypothalamus in rats
Feeding and activity induced by orexin A in the lateral hypothalamus in rats
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DOI：
10.1016/s0167-0115(01)00346-9
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发表时间：
2002-03-15
影响因子：
--
通讯作者：
Wang, CF
中科院分区：
文献类型：
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作者：
Kotz, CM;Teske, JA;Wang, CF
将食欲素A注射到外侧下丘脑（LH）中刺激进食并激活调节进食和唤醒的脑部位中的神经元。食欲素A的进食作用已经在光周期期间（大鼠正常休息的时间）得到证实，并且食欲素A在注射到LH中后对活动的作用先前尚未测量。因此，目前尚不清楚LH食欲素A诱导的进食是否继发于增强的唤醒。为了解决这个问题，在光和暗循环期间，用食欲素A（1000 pmol）或媒介物注射习惯于转轮的LH插管大鼠。测量摄食量和转轮旋转2 h。在黑暗周期期间还测量了自发身体活动（SPA）。在光周期，食欲素A在LH刺激喂养的存在和不存在的转轮和运行轮旋转的存在和不存在的食物的数量增加。在黑暗周期中，LH中的食欲素A诱导SPA（+/-食物存在），但对摄食没有影响。这些数据表明，LH食欲素A刺激进食并不总是与活动增加一致，这表明LH注射食欲素A诱导的进食并不必然增强唤醒。出版社：Elsevier Science B. V.
Orexin A injected into the lateral hypothalamus (LH) stimulates feeding and activates neurons in brain sites regulating feeding and arousal, The feeding effects of orexin A have been demonstrated during the light cycle, a time when rats are normally resting, and the effect of orexin A on activity after injection into the LH has not been previously measured. Thus, it is unclear whether LH orexin A-induced feeding is secondary to enhanced arousal. To address this, LH-cannulated rats habituated to a running wheel were injected with either orexin A (1000 pmol) or vehicle during light and dark cycles. Food intake and running wheel rotations were measured for 2 h. Spontaneous physical activity (SPA) was also measured during the dark cycle. During the light cycle, orexin A in the LH stimulated feeding in the presence and absence of a running wheel and increased number of running wheel rotations in the presence and absence of food. During the dark cycle, orexin A in the LH induced SPA (+/- presence of food), but had no effect on feeding. These data show that LH orexin A stimulation of feeding is not always coincident with increased activity, suggesting that feeding induced by LH-injected orexin A is not consequent to enhanced arousal. Published by Elsevier Science B.V.