New FH peptide-modified ultrasonic nanobubbles for delivery of doxorubicin to cancer-associated fibroblasts
New FH peptide-modified ultrasonic nanobubbles for delivery of doxorubicin to cancer-associated fibroblasts
复制标题
新型 FH 肽修饰超声波纳米泡可将阿霉素递送至癌症相关成纤维细胞
DOI：
10.2217/nnm-2019-0302
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发表时间：
2019-11-01
期刊：
影响因子：
5.5
通讯作者：
Li, Jie
中科院分区：
文献类型：
--
作者：
Guo, Lu;Shi, Dandan;Li, Jie
目的：目的合成并评价一种新型FH肽修饰的阿霉素超声纳米泡（FH-NB-DOX）对肿瘤相关成纤维细胞（CAFs）的靶向性和清除作用。材料和方法：研究了这些NB的特性、细胞毒性、超声造影（CEUI）、靶向性和特异性清除CAFs的能力。结果如下：FH-NB-DOX（约208 nm）显示出良好的CEUI，并且由于FH肽与CAFs中高水平表达的腱生蛋白C蛋白的结合能力而实现了更高的靶向能力。在超声照射下，FH-NB-DOX能将更多的DOX导入CAFs，表现出比NB-DOX和游离DOX更强的根除作用。结论：这些新的NB结合了靶向治疗诊断剂和CEUI的优点，有望成为基于CAF靶向的肿瘤治疗的潜在方法。[图形]
Aim: To synthesize and evaluate a novel FH peptide-modified ultrasonic nanobubble-loading doxorubicin (FH-NB-DOX) for specially cancer-associated fibroblasts (CAFs) targeting and eradication. Materials & methods: The characteristics, cytotoxicity, contrast-enhanced ultrasound imaging (CEUI), targeting ability and specially eradicating CAFs of these NBs were investigated. Results: FH-NB-DOX (about 208 nm) showed a good CEUI, and achieved higher targeting ability due to the conjunction ability of FH peptide to tenascin C protein high-level expressed in CAFs. Under ultrasound irradiation, FH-NB-DOX could delivery more DOX into CAFs, thus exhibited stronger eradication role compared with NB-DOX and free DOX. Conclusion: These new NBs, which combines the advantages of targeted theranostic agent and CEUI, is expected to be a potential approach for tumor therapy based on CAF targeting.[GRAPHICS]