The impact of cystic fibrosis-related diabetes on health-related quality of life
The impact of cystic fibrosis-related diabetes on health-related quality of life
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DOI：
10.1016/j.jcf.2019.03.007
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发表时间：
2019-09-01
影响因子：
5.2
通讯作者：
Quon, Bradley S.
中科院分区：
文献类型：
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作者：
Kwong, Eugenie;Desai, Sameer;Quon, Bradley S.
囊性纤维化相关糖尿病(CFRD)是囊性纤维化人群中众所周知的一种共病。为探讨CFRD是否影响健康相关生活质量(HRQOL)，比较了14岁以上儿童囊性纤维化问卷(CFQ-R14+)中胰岛素治疗组、非胰岛素治疗组、糖耐量减退组和正常血糖耐量组的领域得分。与其他诊断组相比，患有CFRD的患者在治疗负担领域的得分中值显著低于其他诊断组(p<；0.001)，在调整混杂变量后，这种相关性仍然显著。总之，对胰岛素的额外需求显著增加了成人CFRD的治疗负担，因此迫切需要新的策略来减轻这一群体的治疗负担。(C)2019年欧洲囊性纤维化学会。爱思唯尔出版，版权所有。
Cystic fibrosis-related diabetes (CFRD) is a well-known comorbidity among the CF population. To investigate whether CFRD impacts health-related quality of life (HRQoL), domain scores from the Cystic Fibrosis Questionnaire-Revised for adolescents and adults over 14 years old (CFQ-R 14+) were compared between CF individuals with CFRD on insulin, CFRD not on insulin, impaired glucose tolerance, and normal blood glucose tolerance. The median score for the Treatment Burden domain was significantly worse for individuals with CFRD on insulin (p < 0.001) compared to the other diagnostic groups, and this association remained significant following adjustment for confounding variables. In conclusion, the additional requirement for insulin significantly contributes to treatment burden in adults with CFRD and therefore novel strategies to reduce treatment burden for this group are urgently needed. (C) 2019 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.