STRUCTURE AND CONTROL OF PHOSPHOFRUCTOKINASE FROM BACILLUS-STEAROTHERMOPHILUS
STRUCTURE AND CONTROL OF PHOSPHOFRUCTOKINASE FROM BACILLUS-STEAROTHERMOPHILUS
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DOI：
10.1038/279500a0
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发表时间：
1979-01-01
期刊：
影响因子：
64.8
通讯作者：
HUDSON, PJ
中科院分区：
文献类型：
--
作者：
EVANS, PR;HUDSON, PJ
变构酶磷酸果糖激酶[EC 2.7.1.11]在四聚体的2个亚基之间结合底物果糖-6-磷酸，在另一对亚基之间结合变构效应物。效应结合位点可容纳激活剂和抑制剂。底物的协同性和变构控制是由这些亚基之间的配体桥介导的。
The allosteric enzyme phosphofructokinase [EC 2.7.1.11] binds its substrate fructose-6-phosphate between 2 subunits of the tetramer, and allosteric effectors between another pair of subunits. The effector binding site accommodates both the activator and the inhibitor. The substrate cooperativity and allosteric control are mediated by these ligand bridges between subunits.