Sensitivity to change of composite and frequency scores of the Neuropsychiatric Inventory in mild to moderate dementia
Sensitivity to change of composite and frequency scores of the Neuropsychiatric Inventory in mild to moderate dementia
复制标题
DOI：
10.1017/s1041610212001974
复制
发表时间：
2013-03-01
影响因子：
7
通讯作者：
Tribanek, Michael
中科院分区：
文献类型：
--
作者：
Cummings, Jeffrey L.;Ihl, Ralf;Tribanek, Michael
背景：神经精神量表（NPI）被广泛用于评估痴呆的精神病理学。评分涉及频率和严重程度的评级，以及综合评分的计算。最近有人提出，由于方差较低，频率评分可能比综合评分更敏感地检测治疗相关的变化，并区分积极治疗和安慰剂，特别是在疾病的轻度形式。方法：根据三项针对轻度至中度痴呆患者的随机对照试验的数据，计算两个疾病严重程度等级的频率和综合评分的标准化变化。这两个分层是通过将样本沿着简短认知能力测试（SKT）组合的中值得分二分而形成的。结果：在所有研究中，对于两个严重程度分层，频率得分的标准化变化并不总是大于综合得分的标准化变化，并且两个得分以相似的1型错误概率区分活性治疗和安慰剂。我们的研究结果不支持频率评分和综合评分对治疗相关变化的敏感性存在差异的观点。
Background: The Neuropsychiatric Inventory (NPI) is widely used to assess psychopathology in dementia. The scoring involves ratings of frequency and severity, as well as the calculation of a composite score. It was suggested recently that, due to lower variance, the frequency score might be more sensitive to detect treatment-related change and to discriminate active treatment from placebo than the composite score, particularly in milder forms of the disease.Methods: Based on data from three randomized controlled trials in patients with mild to moderate dementia, standardized changes were calculated for both frequency and composite scores for two strata of disease severity. The two strata were formed by dichotomizing the sample along the median score of the short cognitive performance test (SKT) battery.Results: Across all studies and for both severity strata, standardized changes in frequency scores were not consistently larger than those in composite scores and both scores discriminated active treatment from placebo at similar probabilities for type-1 error.Conclusion: Our findings do not support the notion that there is a difference between frequency score and composite score with respect to their sensitivity to treatment-related change.