Synthesis and bioactivity of novel N,N′-diacylhydrazine derivatives containing furan(I)
Synthesis and bioactivity of novel N,N′-diacylhydrazine derivatives containing furan(I)
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DOI：
10.1002/cjoc.200890168
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发表时间：
2008-05-01
影响因子：
5.4
通讯作者：
Chen Fu-Heng
中科院分区：
文献类型：
--
作者：
Cui Zi-Ning;Huang Juan;Chen Fu-Heng
呋喃环体系具有富电子性质和多种生物活性，将其引入到双酰肼中，可以得到新型的先导化合物，有望作为农药和药物的改良剂。以5-氟苯基-2-呋喃甲酰氯和取代苯甲酰肼为原料，在无水二氯甲烷中回流反应，合成了一系列新型含呋喃环的双酰肼衍生物。所合成的化合物的结构经IR、H-1 NMR、MS和元素分析确证。评价了这些新化合物的药理活性和抗肿瘤活性。
The furan ring system possesses electron-rich properties and exhibits various biological activities, which was introduced into diacylhydrazine to create novel leading compounds that may serve as improved pesticides and pharmaceuticals. A series of novel diacylhydrazine derivatives containing a furan ring were synthesized by the reaction of 5-fluorophenyl-2-furoyl chloride with substituted benzoylhydrazide in anhydrous dichloromethane under reflux. The structures of the resultant compounds were confirmed by IR, H-1 NMR, MS and elemental analysis. Insecticidal and anti-tumor activities of these new compounds were evaluated.