Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs
Protection elicited by a double leucine and pantothenate auxotroph of Mycobacterium tuberculosis in guinea pigs
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DOI：
10.1128/iai.72.5.3031-3037.2004
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发表时间：
2004-05-01
影响因子：
3.1
通讯作者：
Hondalus, MK
中科院分区：
文献类型：
--
作者：
Sampson, SL;Dascher, CC;Hondalus, MK
我们开发了一种完全减毒的结核分枝杆菌活疫苗候选菌株，该菌株在亮氨酸和泛酸生物合成中具有两个独立的减毒营养缺陷型突变。DeltaleuD DeltapanCD双营养缺陷型在SCID小鼠模型中完全减毒，在极其敏感的豚鼠结核病模型中具有高度免疫原性和保护性，从而降低细菌负荷和疾病病理学。
We developed a live, fully attenuated Mycobacterium tuberculosis vaccine candidate strain with two independent attenuating auxotrophic mutations in leucine and pantothenate biosynthesis. The DeltaleuD DeltapanCD double auxotroph is fully attenuated in the SCID mouse model and highly immunogenic and protective in the extremely sensitive guinea pig tuberculosis model, reducing both bacterial burden and disease pathology.