Reduced fertility in gracile axonal dystrophy (gad) mice.
Reduced fertility in gracile axonal dystrophy (gad) mice.
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纤细轴突营养不良 (gad) 小鼠的生育能力降低。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
T. Tomita
中科院分区：
文献类型：
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作者：
K. Yamazaki;N. Wakasugi;A. Sakakibara;T. Tomita
在品系内和品系间杂交中，gad/gad雌性的平均窝仔数显著低于正常雌性（+/+和gad/+）。窝仔数的减少不依赖于雄性的基因型，但可以归因于gad/gad雌性本身。交配后14 d，gad/gad组雌鼠的黄体数和着床数均略低于对照组，但活胎数显著低于正常组（P <0.02）。因此，gad/gad雌性动物的窝仔数减少主要是由于着床后胚胎和胎儿死亡所致，推断这是由于子宫功能受损所致。
Mean litter size in gad/gad females was significantly lower than in normal females (+/+ and gad/+) in intra- and inter-strain crosses. The reduction in litter size was not dependent on the genotypes of the males, but could be attributed to the gad/gad females themselves. The numbers of corpora lutea and implants in gad/gad females were slightly reduced as compared with those in the controls, but the number of live fetuses was significantly lower than that in normal females 14 days after copulation (P less than 0.02). Hence, reduced litter size in gad/gad females was accounted for mostly by embryonic and fetal death after implantation, which was inferred to be due to impaired uterine function.