Systemic lupus erythematosus in a multiethnic US cohort, LUMINA (XLIX): preliminary evaluation of the impact of statins on disease activity.
Systemic lupus erythematosus in a multiethnic US cohort, LUMINA (XLIX): preliminary evaluation of the impact of statins on disease activity.
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美国多种族队列中的系统性红斑狼疮，LUMINA (XLIX)：他汀类药物对疾病活动影响的初步评估。
DOI：
10.1097/rhu.0b013e318177a63d
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
LUMINAStudyGroup
中科院分区：
文献类型：
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作者：
Fernández,Mónica;McGwinJr,Gerald;Andrade,Rosa;Bastian,HollyM;Fessler,BarriJ;Reveille,JohnD;Vilá,LuisM;Alarcón,GracielaS;LUMINAStudyGroup
RESULTSOne hundred and fifty-two patients were included in these analyses; thus, 304 intervals were analyzed. Ninety two percent (n 140) of the patients were women and 8%(n 12) were men. Of them, 29 (19%) were Hispanics from Texas, 15 (10%) Hispanics from Puerto Rico, 77 (51%) African Americans, and 31 (20%) whites. The mean age (SD) was 35.0 (11.4) years; the mean disease duration from diagnosis to the case intervals was 4.4 years and it was 4.9 years for the control intervals; the difference not being statistically significant. Within these intervals, 28 exposures to statins had occurred 13 exposures (8.6%) for the cases and 15 (9.9%) for the controls. Exposure to statins was not associated with a decrease in disease activity (odds ratio 0.82, 95% confidence interval 0.34–1.98, P 0.66).
