Development of a Small Animal PET Scanner Using DOI Detectors
Development of a Small Animal PET Scanner Using DOI Detectors
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使用 DOI 探测器开发小动物 PET 扫描仪
DOI：
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发表时间：
2008
影响因子：
1.8
通讯作者：
Eiichi Tanaka
中科院分区：
文献类型：
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作者：
R. Yamada;M. Watanabe;T. Omura;N. Sato;K. Shimizu;M. Takahashi;K. Ote;A. Katabe;T. Moriya;K. Sakai;T. Yamashita;Eiichi Tanaka
使用 256 通道 PS-PMT 的小型动物 PET 扫描仪已被设计、构建和评估。该扫描仪有 12 个探测器模块，每个探测器模块由双层 LYSO 晶体阵列和三个 PS-PMT (Hamamatsu R8400-00-M256) 组成。在LYSO晶体块中，32×53个晶体元件与32×54个晶体元件光学耦合，沿轴向方向偏移一半元件间距。每个晶体元件的横截面尺寸为 1.275 乘以 2.675 mm2，深度为 7 mm。十二个探测器模块位于直径为 182 毫米的环上，形成 107 个探测器环，间距为 1.4 毫米。横轴FOV直径为100毫米，轴向FOV为151毫米，足以覆盖鼠标的整个身体。为了补偿PS-PMT的多阳极输出的不均匀，在前端电路中使用具有64通道可变增益放大器和求和放大器的ASIC。初步实验结果是CFOV中的横轴分辨率为2.0 mm FWHM，环轴上的轴向分辨率为2.8 mm FWHM。对于 CFOV 处的点源，设置 350-750 keV 的能量窗口和 10 ns 的定时窗口，绝对符合灵敏度为 8.1%。扫描仪的适用成像能力已通过大鼠的动物研究得到证明。
A small animal PET scanner using 256-channel PS-PMTs has been designed, constructed, and evaluated. The scanner has twelve detector modules, each of which consists of a double-layer array of LYSO crystals and three PS-PMTs (Hama- matsu R8400-00-M256). In the LYSO crystal block, 32 times 53 crystal elements are optically coupled to 32 times 54 crystal elements with a shift of half the element pitch in the axial direction. The dimension of each crystal element is 1.275 times 2.675 mm2 in cross section and 7 mm in depth. The twelve detector modules are positioned on a 182 mm diameter ring to form 107 detector rings with 1.4 mm pitch. The transaxial FOV is 100 mm in diameter and the axial FOV is 151 mm, which is sufficient to cover the whole body of a mouse. In order to compensate for non-uniform outputs from the multi-anodes of the PS-PMTs, ASICs having 64-channel variable gain amplifiers and summing amplifiers are used in the front-end circuits. The preliminary experimental results are the transaxial resolution of 2.0 mm FWHM in the CFOV, and the axial resolution of 2.8 mm FWHM on the axis of the ring. The absolute coincidence sensitivity is 8.1% for a point source at the CFOV with setting an energy window of 350-750 keV and a timing window of 10 ns. The applicable imaging capability of the scanner was demonstrated by animal studies with a rat.
影响因子：
3.5
作者：
Badawi, RD;Marsden, PK
通讯作者：
Marsden, PK