Extracellular influences on tumour angiogenesis in the aged host.

Extracellular influences on tumour angiogenesis in the aged host.
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DOI:
10.1038/sj.bjc.6604144
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发表时间:
2008-01-29
影响因子:
8.8
通讯作者:
Reed, M. J.
Reed, M. J.
中科院分区:
医学1区
文献类型:
--
作者:
Sprenger, C. C.;Plymate, S. R.;Reed, M. J.

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Whether tumours are epithelial or non-epithelial in origin, it is generally accepted that once they reach a certain size all solid tumours are dependent upon a vascular supply to provide nutrients. Accordingly, there is great interest in how the extracellular environment enhances or inhibits vascular growth. In this minireview, we will examine key extracellular components, their changes with ageing, and discuss how these alterations may influence the subsequent development of tumour vasculature in the aged host. Because of the tight correlation between advanced age and development of prostate cancer, we will use prostate cancer as the model throughout this review.
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