Identification and investigation of Drosophila postsynaptic density homologs.
Identification and investigation of Drosophila postsynaptic density homologs.
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DOI：
10.4137/bbi.s2010
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发表时间：
2008-11-03
影响因子：
5.8
通讯作者：
Featherstone DE
中科院分区：
文献类型：
--
作者：
Liebl FL;Featherstone DE
AMPA受体负责CNS中的快速兴奋性传递，并且这些受体的运输已经涉及LTP和学习与记忆。这些受体存在于突触后致密物中，突触后致密物是将受体连接到下游信号传导组分和神经元细胞骨架的蛋白质网络。为了确定果蝇，黑腹果蝇，是否具有类似的蛋白质阵列中发现的哺乳动物PSD，我们确定了果蝇同源的95.8%的哺乳动物PSD蛋白。我们调查，第一次，这些PSD蛋白，Pod1在果蝇神经肌肉接头GluR簇形成的作用，并发现突变pod1导致在突触的A型受体的特定损失。
AMPA receptors are responsible for fast excitatory transmission in the CNS and the trafficking of these receptors has been implicated in LTP and learning and memory. These receptors reside in the postsynaptic density, a network of proteins that links the receptors to downstream signaling components and to the neuronal cytoskeleton. To determine whether the fruit fly, Drosophila melanogaster, possesses a similar array of proteins as are found at the mammalian PSD, we identified Drosophila homologs of 95.8% of mammalian PSD proteins. We investigated, for the first time, the role of one of these PSD proteins, Pod1 in GluR cluster formation at the Drosophila neuromuscular junction and found that mutations in pod1 resulted in a specific loss of A-type receptors at the synapse.