Genetic analysis of halothane sensitivity in Caenorhabditis elegans.
Genetic analysis of halothane sensitivity in Caenorhabditis elegans.
复制标题
DOI：
10.1126/science.3576211
复制
发表时间：
1987-05
期刊：
影响因子：
56.9
通讯作者：
M. Sedensky;P. Meneely
中科院分区：
文献类型：
--
作者：
M. Sedensky;P. Meneely
秀丽隐杆线虫似乎是研究挥发性麻醉剂作用的有用模型。先前描述了一种对广泛使用的麻醉剂氟烷过敏的突变株。突变现在被证明是unc-79的等位基因。unc-79的其他等位基因也与氟烷过敏有关。另一个基因unc-80发生突变的菌株也对氟烷过敏。同时携带unc-79和unc-80突变的线虫比仅携带其中一种突变的线虫对氟烷稍敏感。第三个基因unc-9的突变会抑制unc-79和unc-80。仅携带抑制基因突变的线虫对氟烷具有正常的敏感性。这些结果表明，对氟烷的敏感性可以通过几个不同基因的突变来改变。
The nematode Caenorhabditis elegans appears to be a useful model for studying the action of volatile anesthetics. A mutant strain that is hypersensitive to the widely used anesthetic halothane was described earlier. The mutation is now shown to be an allele of unc-79. Other alleles of unc-79 are also associated with hypersensitivity to halothane. A strain with a mutation in a second gene, unc-80, is also hypersensitive to halothane. Nematodes bearing mutations in both unc-79 and unc-80 are slightly more sensitive to halothane than those bearing only one of these mutations. Mutations in a third gene, unc-9, suppress both unc-79 and unc-80. Nematodes bearing the suppressor mutations alone have normal sensitivity to halothane. These results show that sensitivity to halothane can be altered by mutations in several different genes.