Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection
Self-delivering nanoemulsions for dual fluorine-19 MRI and fluorescence detection
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DOI：
10.1021/ja077388j
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发表时间：
2008-03-05
影响因子：
15
通讯作者：
Ahrens, Eric T.
中科院分区：
文献类型：
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作者：
Janjic, Jelena M.;Srinivas, Mangala;Ahrens, Eric T.
我们报道了用于双F-19磁共振荧光检测的高度稳定、无毒的全氟聚醚(PFPE)纳米乳剂的设计、合成和生物测试。将线型聚全氟乙烯聚合物与常用荧光染料(FITC、Alexa647和BODIPY-tr)共价偶联，与Pluronic F68和线型聚乙烯亚胺(PEI)混合，微流态化乳化。制备的纳米乳液(
We report the design, synthesis, and biological testing of highly stable, nontoxic perfluoropolyether (PFPE) nanoemulsions for dual F-19 MRI-fluorescence detection. A linear PFPE polymer was covalently conjugated to common fluorescent dyes (FITC, Alexa647 and BODIPy-TR), mixed with pluronic F68 and linear polyethyleneimine (PEI), and emulsified by microfluidization. Prepared nanoemulsions (