IL-6 and IFNγ are elevated in severe mumps cases: a study of 960 mumps patients in China
IL-6 and IFNγ are elevated in severe mumps cases: a study of 960 mumps patients in China
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DOI：
10.3855/jidc.3557
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发表时间：
2014-02-01
影响因子：
1.9
通讯作者：
Li, Wei
中科院分区：
文献类型：
--
作者：
Wang, Wen;Zhu, Yueke;Li, Wei
流行性腮腺炎是一种常见的传染病。方法：收集2010年1月至2012年12月北京佑安医院收治的960例流行性腮腺炎患者的临床资料和实验室检查结果，分析流行性腮腺炎的流行病学特征。选择有孤立并发症的患者，并将其分为无菌性脑膜炎/脑炎（AME）患者（n = 156）和睾丸炎患者（n = 72）。150例无并发症患者作为对照组。结果：腮腺炎患者以男性（76.3%）和17岁以下（76.2%）为主;腮腺炎合并AME占41.6%，睾丸炎占21.3%（64.7%为左侧）。未接种疫苗的患者有更多的机会有AME或睾丸炎（p = 0.034和0.027）。在过去三年中，腮腺炎患者的AME和睾丸炎的发病率迅速增加。没有实验室发现与AME或睾丸炎相关（所有p > 0.05）。几乎所有患者血清IL-10水平均升高。IL-6和IFN γ水平与AME相关（p = 0.025和p = 0.018）。他们的水平在入院后的第一天达到高峰，并开始下降afterseas.Conclusions：这项研究表明，严重并发症的发病率已成为近年来更常见的，而且IL-6和IFN γ可能被用作早期血清标志物，用于识别患者的风险发展并发症在腮腺炎。
Introduction: Mumps is a common infectious disease. Epidemics of mumps are reported globally every year and represent a threat to public health, especially in China and other developing countries.Methodology: Clinical and laboratory findings of 960 mumps patients admitted to Beijing You'an Hospital, China, between January 2010 and December 2012 were collected and analyzed. Patients with isolated complication were selected and grouped as aseptic meningitis/encephalitis (AME) patients (n = 156) and Orchitis patients (n = 72). One hundred and fifty patients without complication were grouped as control. Levels of T cell subtypes and 8 serum cytokines were also tested.Results: Majority of mumps patients were male (76.3%) and younger than 17 years old (76.2%). AME was complicated in 41.6% of mumps cases, and orchitis was in 21.3% (64.7% were left-sided). Unvacinated patients had more chance to have AME or orchitis (p = 0.034 and 0.027). The rates of AME and orchitis in mumps patients rapidly increased during the last three years. No laboratory findings were associated with AME or orchitis (all p > 0.05). Serum IL-10 level was elevated in almost all patients. IL-6 and IFN gamma levels were correlated with AME (p = 0.025 and p = 0.018). Their levels peaked at day one after admission, and started to decline thereafter.Conclusions: This study suggests that the incidence of serious complications has become more common in recent years, moreover IL-6 and IFN gamma may possibly be used as early serum markers for identifying patients with risk of developing complications in mumps.