Multidrug-resistant tuberculosis in South Korea: a retrospective analysis of national registry data in 2011-2015
Multidrug-resistant tuberculosis in South Korea: a retrospective analysis of national registry data in 2011-2015
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DOI：
10.5588/ijtld.18.0658
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发表时间：
2019-07-01
影响因子：
4
通讯作者：
Yim, J-J.
中科院分区：
文献类型：
--
作者：
Lee, M.;Han, J.;Yim, J-J.
背景技术背景：耐多药结核病（MDR-TB）由于治疗费用高和治疗效果不理想，对公共卫生构成威胁。目的：阐明2011年至2015年韩国MDR-TB患者的趋势、人口统计学和临床特征以及治疗结果。从全国互联网结核病通报系统中检索2011年1月1日至2015年12月31日诊断的耐多药结核病患者数据，并进行回顾性分析。在研究期间，共通报了5192名耐多药结核病患者。我们发现，外国人群中耐多药结核病患者的数量不断增加（从1.3%增加到7.7%），对其他抗结核药物的耐药率不断下降（例如，吡嗪酰胺耐药率从40.9%降至28.2%，从治疗开始至痰培养阴转的时间间隔缩短（从165.7天降至103.7天），治疗持续时间缩短（从719.7天降至613.2天）。然而，治疗成功率没有改变，平均为65.7%。结论：尽管对其他药物的耐药率降低，治疗反应更快，但治疗结果在研究期间没有改善。应严格管理耐多药结核病患者的治疗，以改善治疗效果。
BACKGROUND : Multidrug-resistant tuberculosis (MDR-TB) poses a threat to public health as a result of high treatment costs and unsatisfactory outcomes.OBJECTIVE: To elucidate trend, demographic and clinical characteristics and treatment outcomes of patients with MDR-TB between 2011 and 2015 in South Korea.METHOD: Data of patients with MDR-TB diagnosed between 1 January 2011 and 31 December 2015 were retrieved from the nationwide Internet-based TB notification system and analysed retrospectively.RESULTS: During the study period, 5192 MDR-TB patients were notified. We identified an increasing number of MDR-TB patients among foreign populations (from 1.3% to 7.7%), decreasing resistance rates to other anti-TB drugs (e.g., resistance to pyrazinamide, from 40.9% to 28.2%), a decreasing interval from treatment initiation to negative conversion of sputum culture (from 165.7 to 103.7 days) and shortening of treatment duration (719.7 to 613.2 days). However, treatment success rates did not change, and had an average of 65.7%.CONCLUSION: Despite decreasing resistance rates to other drugs and faster treatment responses, treatment outcomes did not improve during the study period. Strict management of MDR-TB patients on treatment should be adopted to improve treatment outcomes.