Asymmetric Photoinduced Giese Radical Addition Enabled by a Single Chiral-at-Metal Rhodium Complex
Asymmetric Photoinduced Giese Radical Addition Enabled by a Single Chiral-at-Metal Rhodium Complex
复制标题
单一手性金属铑配合物实现不对称光诱导吉斯自由基加成
DOI：
10.6023/cjoc202004041
复制
发表时间：
2020-11-25
影响因子：
1.9
通讯作者：
Kang, Qiang
中科院分区：
文献类型：
--
作者：
Chen, Liang;Hu, Liangjian;Kang, Qiang
发展了一种双功能手性金属铑配合物催化的可见光驱动的不对称Giese自由基加成反应。对氨基苯乙酸生成的对氨基苄基自由基可与α，β-不饱和2-酰基咪唑进行1，4-加成反应，得到了一系列具有良好对映选择性的中高产率加成产物.该反应具有对映选择性高、反应条件温和、操作简便等特点。基于我们的研究和文献先例，提出了一个合理的反应机理双功能手性金属催化。
A visible-light driven asymmetric Giese radical addition catalyzed by a bifunctional chiral-at-metal rhodium complex has been developed. para-Aminobenzyl radicals generated from para-aminophenylacetic acids could undergo a 1,4-addition in a highly enantioselective approach to α,β-unsaturated 2-acyl imidazoles, and a variety of corresponding adducts were obtained in moderate to high yields with excellent enantioselectivities. This reaction features high enantioselectivity, mild reaction conditions and an operationally simple procedure. A plausible reaction mechanism is proposed based on our research and literature precedents on dual functional chiral-at-metal catalysis.