The effect of nifedipine and verapamil on the pendular movements of the rabbit isolated ileum
The effect of nifedipine and verapamil on the pendular movements of the rabbit isolated ileum
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硝苯地平和维拉帕米对家兔离体回肠钟摆运动的影响
DOI：
10.1111/j.2042-7158.1985.tb05062.x
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发表时间：
1985
影响因子：
3.3
通讯作者：
Danica Jovanović‐mićić
中科院分区：
文献类型：
--
作者：
D. Beleslin;R. Samardz̆ić;B. Terzić;Danica Jovanović‐mićić
本文观察了钙拮抗剂硝苯地平和维拉帕米对家兔离体回肠摆动运动的抑制作用。硝苯地平和维拉帕米抑制或消除摆动运动。硝苯地平和维拉帕米的抑制作用具有浓度依赖性。硝苯地平的药效比维拉帕米强1000倍。钙离子不能逆转硝苯地平和维拉帕米的抑制作用。因此，影响消化道运动活性的钙拮抗剂可具有与其对心血管系统的作用无关的治疗用途。
The inhibitory effect of calcium antagonists such as nifedipine and verapamil on the pendular movements of the rabbit isolated ileum was investigated. Nifedipine and verapamil depressed or abolished the pendular movements. The inhibitory effects of nifedipine and verapamil were concentration‐dependent. Nifedipine is about 1000 times more potent than verapamil. Calcium ions failed to reverse the inhibitory effects of nifedipine and verapamil. Calcium antagonists which influence the motor activity of the digestive tract, therefore, could have therapeutic use independent of their action on the cardiovascular system.