Synthesis and antibacterial activity of oxazolidinones containing triazolyl group
Synthesis and antibacterial activity of oxazolidinones containing triazolyl group
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DOI：
10.1016/j.ejmech.2007.01.012
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发表时间：
2007-08-01
影响因子：
6.7
通讯作者：
Ji, Ruyun
中科院分区：
文献类型：
--
作者：
Fan, Houxing;Xu, Gang;Ji, Ruyun
合成了一系列新的含有三唑基的恶唑烷酮，并通过针对一组耐药和敏感革兰氏阳性生物的 MIC 测定来测试其体外抗菌活性。该系列中的大多数类似物在体外表现出优于利奈唑胺和万古霉素的活性。此外，本文还公开了所选恶唑烷酮的体内功效。 (c) 2007 年 Elsevier Masson SAS。版权所有。
A new series of oxazolidinones containing triazolyl group has been synthesized and tested for in vitro antibacterial activity by MIC determination against a panel of resistant and susceptible Gram-positive organisms. Most of the analogs in this series displayed activity superior to linezolid and vancomycin in vitro. Further, in vivo efficacies of the selected oxazolidinones were also disclosed herein. (c) 2007 Elsevier Masson SAS. All rights reserved.