Seasonal regulation of the lncRNA LDAIR modulates self-protective behaviours during the breeding season
Seasonal regulation of the lncRNA LDAIR modulates self-protective behaviours during the breeding season
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DOI：
10.1038/s41559-019-0866-6
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发表时间：
2019-05-01
影响因子：
16.8
通讯作者：
Yoshimura, Takashi
中科院分区：
文献类型：
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作者：
Nakayama, Tomoya;Shimmura, Tsuyoshi;Yoshimura, Takashi
为了科普季节性的环境变化，动物会根据光周期调整其生理和行为。然而，这些适应性变化的分子机制尚未完全理解。在这里，使用全基因组表达分析，我们表明，一个不具特征的长非编码RNA（lncRNA），LDAIR，强烈受光周期在日本青鳉鱼（Oryzias latipes）。在从短日照条件到长日照条件的过渡期间，许多转录物和信号传导途径被激活;然而，LDAIR是第一个被诱导的基因之一，并且其表达在长日照条件下显示出稳健的每日节律。LDAIR基因敲除鱼的转录组分析表明，LDAIR基因座调节的基因附近，包括促肾上腺皮质激素释放激素受体2，这是参与应激反应。LDAIR敲除鱼的行为分析表明，LDAIR影响长日照条件下的自我保护行为。因此，我们建议，光周期调节促肾上腺皮质激素释放激素受体2的LDAIR调制适应行为的季节性环境变化。
To cope with seasonal environmental changes, animals adapt their physiology and behaviour in response to photoperiod. However, the molecular mechanisms underlying these adaptive changes are not completely understood. Here, using genome-wide expression analysis, we show that an uncharacterized long noncoding RNA (lncRNA), LDAIR, is strongly regulated by photoperiod in Japanese medaka fish (Oryzias latipes). Numerous transcripts and signalling pathways are activated during the transition from short- to long-day conditions; however, LDAIR is one of the first genes to be induced and its expression shows a robust daily rhythm under long-day conditions. Transcriptome analysis of LDAIR knockout fish reveals that the LDAIR locus regulates a gene neighbourhood, including corticotropin releasing hormone receptor 2, which is involved in the stress response. Behavioural analysis of LDAIR knockout fish demonstrates that LDAIR affects self-protective behaviours under long-day conditions. Therefore, we propose that photoperiodic regulation of corticotropin releasing hormone receptor 2 by LDAIR modulates adaptive behaviours to seasonal environmental changes.