Acute-onset chronic inflammatory demyelinating polyneuropathy with focal segmental glomerulosclerosis
Acute-onset chronic inflammatory demyelinating polyneuropathy with focal segmental glomerulosclerosis
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DOI：
10.1016/j.jns.2014.03.040
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发表时间：
2014-06-15
影响因子：
4.4
通讯作者：
Yuki, Nobuhiro
中科院分区：
文献类型：
--
作者：
Quek, Amy May Lin;Soon, Derek;Yuki, Nobuhiro
据报道，炎症性神经病变与肾病综合征有关。其潜在的免疫致病机制尚不清楚。一位50岁的女性同时表现为急性发作的慢性炎症性脱髓鞘性多神经病变和继发于局灶节段性肾小球硬化的肾病综合征。血浆置换和类固醇治疗后，神经病变和蛋白尿均有改善。文献回顾的病例并发炎性神经病和肾病综合征显示类似的神经肾脏表现。这种神经肾脏疾病可能是由针对髓磷脂和足细胞的自身抗体介导的。(C) 2014 Elsevier B.V.版权所有
Inflammatory neuropathies have been reported to occur in association with nephrotic syndrome. Their underlying immuno-pathogenic mechanisms remain unknown. A 50-year-old woman concurrently presented with acute-onset chronic inflammatory demyelinating polyneuropathy and nephrotic syndrome secondary to focal segmental glomerulosclerosis. Both neuropathy and proteinuria improved after plasma exchange and steroids. Literature review of cases of concurrent inflammatory neuropathies and nephrotic syndrome revealed similar neuro-renal presentations. This neuro-renal condition may be mediated by autoantibodies targeting myelin and podocytes. (C) 2014 Elsevier B.V. All rights reserved.