The Exercising Brain: Changes in Functional Connectivity Induced by an Integrated Multimodal Cognitive and Whole-Body Coordination Training.
The Exercising Brain: Changes in Functional Connectivity Induced by an Integrated Multimodal Cognitive and Whole-Body Coordination Training.
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DOI：
10.1155/2016/8240894
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发表时间：
2016
影响因子：
3.1
通讯作者：
Ende G
中科院分区：
文献类型：
--
作者：
Demirakca T;Cardinale V;Dehn S;Ruf M;Ende G
本研究通过增加静息状态功能磁共振成像(rs-fMRI)过程中的功能连接性，研究了“生活运动”训练对大脑可塑性的影响。训练是一种综合的多模式训练，将运动和认知方面结合起来，通过引入新的和不熟悉的协调任务来挑战大脑。21名受试者在13周内完成了每周至少11次每周一小时的运动训练课程，同时完成了rs-fmri扫描前后的训练。此外，11名对照受试者接受了两次rS-fMRI扫描。Conn工具箱用于执行几个种子到体素的分析。我们寻找在练习中预期涉及的大脑区域之间的功能连接增加。与代表默认模式网络部分的大脑区域，如内侧额叶皮质和后扣带皮质的连接没有改变。在视觉皮质和部分顶上区域之间发生了显著的连接改变(Ba7)。运动前区和扣带回也受到影响。我们可以得出结论，不熟悉的协调任务组合的持续挑战，再加上视觉感知和工作记忆需求，似乎诱发了大脑可塑性，表现为由于共激活而增强了脑区的连接强度。
This study investigated the impact of “life kinetik” training on brain plasticity in terms of an increased functional connectivity during resting-state functional magnetic resonance imaging (rs-fMRI). The training is an integrated multimodal training that combines motor and cognitive aspects and challenges the brain by introducing new and unfamiliar coordinative tasks. Twenty-one subjects completed at least 11 one-hour-per-week “life kinetik” training sessions in 13 weeks as well as before and after rs-fMRI scans. Additionally, 11 control subjects with 2 rs-fMRI scans were included. The CONN toolbox was used to conduct several seed-to-voxel analyses. We searched for functional connectivity increases between brain regions expected to be involved in the exercises. Connections to brain regions representing parts of the default mode network, such as medial frontal cortex and posterior cingulate cortex, did not change. Significant connectivity alterations occurred between the visual cortex and parts of the superior parietal area (BA7). Premotor area and cingulate gyrus were also affected. We can conclude that the constant challenge of unfamiliar combinations of coordination tasks, combined with visual perception and working memory demands, seems to induce brain plasticity expressed in enhanced connectivity strength of brain regions due to coactivation.