Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa.
Ocular surface squamous neoplasia in patients with HIV infection in sub-Saharan Africa.
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DOI：
10.1097/cco.0b013e32833cfcf9
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发表时间：
2010-09
影响因子：
3.4
通讯作者：
Remick SC
中科院分区：
文献类型：
--
作者：
Nagaiah G;Stotler C;Orem J;Mwanda WO;Remick SC
撒哈拉以南非洲国家的眼表鳞状细胞瘤（OSSN）是一种侵袭性肿瘤，影响年轻患者，发病率似乎在增加。有数据表明这种疾病与太阳辐射暴露，艾滋病毒和人乳头瘤病毒（HPV）有关。这一趋势可能反映了艾滋病毒的高发病率，随之而来的高发病率暴露于HPV，以及太阳辐射暴露，人们在世界上的这一地区的关联。我们使用“眼表鳞状细胞瘤”、“结膜癌”、“HIV”和“HPV”以及“撒哈拉以南/非洲”等术语进行了PubMed检索，以确定问题的范围并回顾现有数据，重点是2009年和2010年第一季度的出版物。有越来越多的证据表明，艾滋病毒血清阳性和OSSN之间的显着关联。HPV作为OSSN病因的作用正在研究中。撒哈拉以南非洲的结膜癌患者通常较年轻，超过50%的患者有潜在的HIV感染。最初的表现可能是无症状的;然而，这些患者中的许多人在寻求医疗帮助之前已经患有晚期疾病，并且OSSN似乎在撒哈拉以南非洲具有更积极的临床过程。非洲的治疗主要是外科手术。化疗和抗病毒药物已被使用。在撒哈拉以南非洲地区的年轻患者中诊断出OSSN应该会促进艾滋病毒血清检测。
Ocular surface squamous neoplasia (OSSN) in sub-Saharan countries is an aggressive tumor that affects younger patients and appears to be increasing in incidence. There are data to suggest the association of this disease with solar radiation exposure, HIV, and human papilloma virus (HPV). This trend possibly reflects the association of the high incidence of HIV, concomitant high incidence of exposure to HPV, and the solar radiation exposure that people in this region of the world receive. We undertook a PubMed search with the terms ‘ocular surface squamous neoplasia’, ‘conjunctival carcinoma’, ‘HIV’ and ‘HPV’, and ‘sub-Saharan/Africa’ to ascertain the scope of the problem and to review the available data, with an emphasis on publications of 2009 and the first quarter of 2010. There is increasing evidence of a significant association between HIV seropositivity and OSSN. The role of HPV as contributing to the cause of OSSN is being investigated. Patients with conjunctival cancer in sub-Saharan Africa are typically younger and more than 50% have underlying HIV infection. Initial presentation can be asymptomatic; however, many of these patients have advanced disease before they seek medical help and OSSN appears to have a more aggressive clinical course in sub-Saharan Africa. Treatment in Africa is primarily surgical. Chemotherapy and antiviral agents have been used. A diagnosis of OSSN in younger patients in sub-Saharan Africa should prompt HIV serotesting.