Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity The TREAT Randomized Clinical Trial
Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity The TREAT Randomized Clinical Trial
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DOI：
10.1001/jamainternmed.2020.4153
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发表时间：
2020-09-28
影响因子：
39
通讯作者：
Weiss, Ethan J.
中科院分区：
文献类型：
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作者：
Lowe, Dylan A.;Wu, Nancy;Weiss, Ethan J.
重要性 限时饮食的有效性和安全性尚未在大型随机临床试验中进行探讨。 目的 确定 16:8 小时限时饮食对体重减轻和代谢风险标志物的影响。 干预措施 参与者被随机分配，要求一致进餐时间 (CMT) 组每天吃 3 顿结构化膳食，限时饮食 (TRE) 组被指示从中午 12:00 开始随意进食晚上 8:00 并从晚上 8:00 到第二天中午 12:00 完全禁止摄入热量。 设计、设置和参与者 这项为期 12 周的随机临床试验包括年龄在 18 至 64 岁之间的男性和女性，体重指数（BMI，按体重公斤数除以身高米平方计算）为 27 至 43，在定制移动研究应用程序上进行。参与者收到了蓝牙秤。参与者居住在美国任何地方，其中 50 名参与者居住在加利福尼亚州旧金山附近，他们接受了现场测试。 主要结果和措施 主要结果是体重减轻。现场队列的次要结果包括体重、脂肪量、瘦体重、空腹胰岛素、空腹血糖、血红蛋白 A(1c) 水平、估计能量摄入量、总能量消耗和静息能量消耗的变化。 结果 总体而言，该研究纳入了 116 名参与者（平均 [SD] 年龄，46.5 [10.5] 岁；70 [60.3%] 男性）。 TRE 组体重显着下降（-0.94 kg；95% CI，-1.68 至 -0.20；P = .01），但 CMT 组（-0.68 kg；95% CI，-1.41 至 0.05，P = .07）或组间（-0.26 kg；95% CI，-1.30 至 0.78；P）没有显着变化= .63）。在面对面队列（n = 25 TRE，n = 25 CMT）中，TRE 组组内体重显着下降（-1.70 kg；95% CI，-2.56 至 -0.83；P < .001）。各组之间的四肢去脂质量指数也存在显着差异（-0.16 kg/m(2)；95% CI，-0.27 至 -0.05；P = .005）。组内或组间的任何其他次要结果均无显着变化。各组之间的估计能量摄入量没有差异。结论和相关性在没有其他干预措施的情况下，限时饮食并不比全天饮食更有效。
IMPORTANCE The efficacy and safety of time-restricted eating have not been explored in large randomized clinical trials.OBJECTIVE To determine the effect of 16:8-hour time-restricted eating on weight loss and metabolic risk markers.INTERVENTIONS Participants were randomized such that the consistent meal timing (CMT) group was instructed to eat 3 structured meals per day, and the time-restricted eating (TRE) group was instructed to eatad libitumfrom 12:00pmuntil 8:00pmand completely abstain from caloric intake from 8:00pmuntil 12:00pmthe following day.DESIGN, SETTING, AND PARTICIPANTS This 12-week randomized clinical trial including men and women aged 18 to 64 years with a body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) of 27 to 43 was conducted on a custom mobile study application. Participants received a Bluetooth scale. Participants lived anywhere in the United States, with a subset of 50 participants living near San Francisco, California, who underwent in-person testing.MAIN OUTCOMES AND MEASURES The primary outcome was weight loss. Secondary outcomes from the in-person cohort included changes in weight, fat mass, lean mass, fasting insulin, fasting glucose, hemoglobin A(1c)levels, estimated energy intake, total energy expenditure, and resting energy expenditure.RESULTS Overall, 116 participants (mean [SD] age, 46.5 [10.5] years; 70 [60.3%] men) were included in the study. There was a significant decrease in weight in the TRE (-0.94 kg; 95% CI, -1.68 to -0.20;P = .01), but no significant change in the CMT group (-0.68 kg; 95% CI, -1.41 to 0.05,P = .07) or between groups (-0.26 kg; 95% CI, -1.30 to 0.78;P = .63). In the in-person cohort (n = 25 TRE, n = 25 CMT), there was a significant within-group decrease in weight in the TRE group (-1.70 kg; 95% CI, -2.56 to -0.83;P < .001). There was also a significant difference in appendicular lean mass index between groups (-0.16 kg/m(2); 95% CI, -0.27 to -0.05;P = .005). There were no significant changes in any of the other secondary outcomes within or between groups. There were no differences in estimated energy intake between groups.CONCLUSIONS AND RELEVANCE Time-restricted eating, in the absence of other interventions, is not more effective in weight loss than eating throughout the day.