Amygdala and insula response to emotional images in patients with generalized social anxiety disorder.
Amygdala and insula response to emotional images in patients with generalized social anxiety disorder.
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发表时间：
2009-07
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通讯作者：
Sabina Shah;H. Klumpp;Mike Angstadt;P. Nathan;K. Phan
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作者：
Sabina Shah;H. Klumpp;Mike Angstadt;P. Nathan;K. Phan
背景脑功能成像研究表明，广泛性社交焦虑症(GSAD)患者的杏仁核和脑岛对社会威胁的探测具有高反应性。众所周知，杏仁核和脑岛在情绪处理中具有广泛的功能，包括整合情感信息。然而，很少有研究研究社交焦虑参与者在一般情绪处理过程中的大脑反应。我们检测了GSAD患者和匹配的健康对照组的大脑对情绪唤起图像的反应。方法对11例未服用精神药物且无精神合并症的GSAD患者和11例匹配的健康对照组进行功能磁共振成像，同时观看情绪显着(阳性、阴性、中性)图像块。结果与未表现出增强反应性的健康对照组相比，GSAD患者的双侧杏仁核和脑岛对阴性(v.中性)图像的反应性增强。在GSAD组中，杏仁核激活的程度与社交焦虑的严重程度相关，而脑岛的激活程度与特质焦虑相关。限制小样本量可能限制了我们在其他相关大脑区域和行为测量中发现群体差异的能力。结论除了社会信息加工的前人发现外，我们的发现还表明杏仁核和岛叶反应对具有负面情绪内容的一般情绪图像具有高反应性，这两个脑区在不同表型的表征中可能发挥着不同的作用。
BACKGROUND Functional brain imaging studies have demonstrated amygdala and insula hyper-reactivity to probes of social threat in participants with generalized social anxiety disorder (gSAD). The amygdala and insula are known to serve broad functions in emotional processing, including integration of affective information. However, few studies have examined brain responses in socially anxious participants during general emotional processing. We examined brain response to emotionally evocative images in patients with gSAD and matched healthy controls. METHODS Eleven patients with gSAD who were not taking psychotropic medications and did not have psychiatric comorbidities and 11 matched healthy controls underwent functional magnetic resonance imaging while viewing blocks of emotionally salient (positive, negative, neutral) pictures. RESULTS Participants with gSAD exhibited enhanced bilateral amygdala and insula reactivity to negative (v. neutral) images compared with healthy controls who did not exhibit enhanced reactivity. Within the gSAD group, the extent of amygdala activation was correlated with social anxiety severity, whereas the extent of insula activation was correlated with trait anxiety. LIMITATIONS The small sample size may have limited our ability to detect group differences in other relevant brain regions and in behavioural measures. CONCLUSION In addition to prior findings of probes of social information processing, our findings suggest that the amygdala and insula responses are hyper-reactive to general emotional images with negative emotional content and that these brain regions may play divergent roles in their representation of different phenotypes.